128346-27-0Relevant academic research and scientific papers
Investigation of Chemical Stability of Dihalogenated Organotelluranes in Organic-Aqueous Media: The Protagonism of Water
Teixeira, Mariana L.,Menezes, Leociley R. A.,Barison, Andersson,De Oliveira, Alfredo R. M.,Piovan, Leandro
, p. 7341 - 7346 (2018)
The biological activity of tellurium compounds is closely related to the tellurium oxidation state or some of their structural features. Hypervalent dihalogenated organotelluranes 1-[butyl(dichloro)-λ4-tellanyl]-2-(methoxymethyl)benzene (1a) an
Synthesis, Mechanism Elucidation and Biological Insights of Tellurium(IV)-Containing Heterocycles
Souza, Jo?o Pedro A.,Menezes, Leociley R. A.,Garcia, Francielle P.,Scariot, Débora B.,Bandeira, Pamela T.,Bespalhok, Mateus B.,Giese, Siddhartha O. K.,Hughes, David L.,Nakamura, Celso V.,Barison, Andersson,Oliveira, Alfredo R. M.,Campos, Renan B.,Piovan, Leandro
supporting information, p. 14427 - 14437 (2021/09/25)
Inspired by the synthetic and biological potential of organotellurium substances, a series of five- and six-membered ring organotelluranes containing a Te?O bond were synthesized and characterized. Theoretical calculations elucidated the mechanism for the oxidation-cyclization processes involved in the formation of the heterocycles, consistent with chlorine transfer to hydroxy telluride, followed by a cyclization step with simultaneous formation of the new Te?O bond and deprotonation of the OH group. Moreover, theoretical calculations also indicated anti-diastereoisomers to be major products for two chirality center–containing compounds. Antileishmanial assays against Leishmania amazonensis promastigotes disclosed 1,2λ4-oxatellurane LQ50 (IC50=4.1±1.0; SI=12), 1,2λ4-oxatellurolane LQ04 (IC50=7.0±1.3; SI=7) and 1,2λ4-benzoxatellurole LQ56 (IC50=5.7±0.3; SI=6) as more powerful and more selective compounds than the reference, being up to four times more active. A stability study supported by 125Te NMR analyses showed that these heterocycles do not suffer structural modifications in aqueous-organic media or at temperatures up to 65 °C.
3H(3R)-benzo-2,1-oxatelluroles as synthons in synthesis of o-alkyltellurophenyl carbonyl compounds
Sadekov, Igor D.,Maksimenko, Alexander A.,Minkin, Vladimir I.
, p. 3365 - 3374 (2007/10/03)
A convenient method, developed for the preparation of o-alkyltelluro-benzaldehydes and -phenyl-ketones from o-alkyltellurobenzyl alcohols, involves the intermediate formation and rearrangement of 3H(3R)-benzo-2,1-oxatelluroles, a novel tellurium-containin
5H-1,2-OXATELLUROLES AND THEIR BENZO ANALOGS: SYNTHESIS AND REACTIONS
Sadekov, I. D.,Maksimenko, A. A.,Zakharov, A. V.,Rivkin, B. B.
, p. 243 - 254 (2007/10/02)
Tetracoordinated derivatives of 2-halo-2-aryl-5H-1,2-oxatelluroles and 1-halo-1-butyl-3H-benz-2,1-oxatelluroles were synthesized by the oxidation of 3-aryltelluro-2-propen-1-ols and the dehydrogenation of 2-butyldihalotellurobenzyl alcohols.The halogen at
