128349-09-7

Upstream product

• 98-01-1 furfural 
• 151-50-8 potassium cyanide 
• 100-46-9 benzylamine 
• 773837-37-9 sodium cyanide 
• 557-21-1 zinc(II) cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 1404296-14-5 methyl 2-({benzyl[cyano(furan-2-yl)methyl]amino}methyl)acrylate 

Relevant academic research and scientific papers

γ-Al2O3-supported 12-tungstosilicic acid as an efficient heterogeneous catalyst for the synthesis of α-aminonitrile

The multicomponent Strecker reaction using trimethylsilyle cyanide was performed in very short reaction times, and α-aminonitriles were prepared in excellent yields in the presence of a catalytic amount of alumina-supported tungstosilicic acid. Copyright Taylor & Francis Group, LLC.

Iodine as a novel and efficient reagent for the synthesis of α-aminonitriles by a three-component condensation of carbonyl compounds, amines, and trimethylsilyl cyanide

A straightforward and general method has been developed for the synthesis of α-aminonitriles by simply combining aldehydes or ketones, amines, and trimethylsilyl cyanides in the presence of a catalytic amount of molecular iodine at room temperature.

Vanadyl triflate as an efficient and recyclable catalyst for the synthesis of α-aminonitriles

Vanadyl triflate to catalyzed Strecker-type reactions were successfully carried out by simply mixing aldehydes, amines, and trimethylsilyl cyanide at room temperature to afford α-aminonitriles in good yields. Copyright Taylor & Francis, Inc.

Indium trichloride catalyzed one-step synthesis of α-amino nitriles by a three-component condensation of carbonyl compounds, amines and potassium cyanide

A simple and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes or ketones, amines and potassium cyanide in THF in presence of a catalytic amount of indium trichloride.

Bismuth trichloride catalyzed synthesis of α-aminonitriles

A simple and efficient one-pot method has been developed for the synthesis of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide in the presence of a catalytic amount of bismuth trichloride.

K5CoW12O40·3H2O: Heterogeneous catalyst for the strecker-type aminative cyanation of aldehydes and ketones

One-step synthesis of α-aminonitriles was successfully carried out by a three-component condensation of aldehydes or ketones, amines, and potassium cyanide in the presence of a catalytic amount of K5CoW12O40·3H2O as an efficient, reusable, and nontoxic catalyst. Copyright Taylor & Francis Group, LLC.

Fe3O4?SiO2 nanoparticles–functionalized Cu(II) Schiff base complex with an imidazolium moiety as an efficient and eco-friendly bifunctional magnetically recoverable catalyst for the Strecker synthesis in aqueous media at room temperature

Cu(II) Schiff base complex supported on Fe3O4?SiO2 nanoparticles was employed as a magnetic nanocatalyst (nanocomposite) with a phase transfer functionality for the one-pot preparation of α-aminonitriles (Strecker reaction). The desired α-aminonitriles were obtained from the reaction of aromatic or aliphatic aldehydes, aniline or benzyl amine, NaCN, and 1.6 mol% of the catalyst in water at room temperature and good to excellent yields were obtained for all substrates. The catalyst was characterized analytically and instrumentally including Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric, nuclear magnetic resonance, energy-dispersive X-ray spectroscopy, inductively coupled plasma spectroscopy, vibrating-sample magnetometry analysis, dynamic light scattering, Brunauer–Emmett–Teller surface area, field emission scanning electron microscopy, and transmission electron microscopy analyses. The reaction mechanism was investigated, in which the performance of the catalyst as a phase transition factor seems to be probable. The catalyst showed high activity, high turnover frequency (TOF)s, significant selectivity, and fast performance toward the Strecker synthesis. The nanocatalyst can be readily and quickly separated from the reaction mixture with an external magnet and can be reused for at least seven successive reaction cycles without significant reduction in efficiency.

Magnetic Fe3O4-BF3: Highly efficient Lewis acid catalyst for the synthesis of α-aminonitriles

Fe3O4 magnetic nanoparticle-supported BF3 was prepared as a new magnetically separable Lewis acid catalyst and successfully used for the one-pot synthesis of α-aminonitriles. A broad range of substrates including the aromatic and heteroaromatic aldehydes, cyclic ketones (cyclopentanone, cyclohexanone and cycloheptanone), aryl-alkyl ketones, diaryl ketones and tetralones, isatin derivatives and acenaphthenequinone were condensed with amines (aliphatic and aromatic) and trimethylsilyl cyanide. All reactions were completed in short times and products were obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency. Finally, α-aminonitrile containing adenine was successfully synthesized.

Mechanochemical Strecker Reaction: Access to α-Aminonitriles and Tetrahydroisoquinolines under Ball-Milling Conditions

A mechanochemical version of the Strecker reaction for the synthesis of α-aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2gave the corresponding α-aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.

Zinc triflate a water compatible, green catalyst in one pot three-component efficient synthesis of α-Amino nitriles

α-Amino nitriles are synthesized in one pot three-component coupling of aldehydes, amines and trimethylsilyl cyanide using catalytic amount of zinc triflate at ambient temperature.