1283569-01-6Relevant academic research and scientific papers
Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1
Tallant, Matthew D.,Duan, Maosheng,Freeman, George A.,Ferris, Robert G.,Edelstein, Mark P.,Kazmierski, Wieslaw M.,Wheelan, Pat J.
, p. 1394 - 1398 (2011/04/16)
We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat PK model.
