128403-23-6

Basic information

• Product Name: N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide
• Synonyms: N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide
• CAS NO: 128403-23-6
• Molecular Weight: 231.174
• Mol File: 128403-23-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide(128403-23-6)
• EPA Substance Registry System: N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide(128403-23-6)

Safety Data

• Hazardous Substances Data: 128403-23-6(Hazardous Substances Data)

Upstream product

• 128403-22-5 2-nitro-4-trifluoromethyl-acetophenone 
• 37885-07-7 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 346-55-4 4-chloro-7-trifluoromethyl quinoline 

Relevant articles and documents

Addition of nitroalkanes toortho-halonitrobenzenes: A new synthesis of 4-chloro-7-(trifluoromethyl)quinoline

Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction provides aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl)quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54,669, 1).