1284211-21-7

Basic information

• Product Name: C₂₂H₂₂N₂O₄
• Synonyms: C₂₂H₂₂N₂O₄
• CAS NO: 1284211-21-7
• Molecular Weight: 378.428
• Mol File: 1284211-21-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₂N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₂N₂O₄(1284211-21-7)
• EPA Substance Registry System: C₂₂H₂₂N₂O₄(1284211-21-7)

Safety Data

• Hazardous Substances Data: 1284211-21-7(Hazardous Substances Data)

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 1284211-20-6 C₂₃H₂₄N₂O₄ 
• 38041-19-9 4-aminotetrahydropyran 

Downstream Products

• 1262846-48-9 N-((R)-cyano-methyl-methyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide 
• 1262846-50-3 N-((S)-cyano-methyl-methyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide 
• 1333335-02-6 N-((R)-cyano-methyl-methyl)-3-[5-(4-{[(tetrahydropyran-4-yl)-(2,2,2-trifluoroacetyl)amino]methyl}phenyl)isoxazol-3-yl]benzamide 
• 1333341-24-4 C₂₇H₂₅F₃N₄O₄ 
• 1262847-74-4 N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide 

Relevant articles and documents

3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

The synthesis and preliminary studies of the SAR of novel 3,5-diarylazole inhibitors of Protein Kinase D (PKD) are reported. Notably, optimized compounds in this class have been found to be active in cellular assays of phosphorylation-dependant HDAC5 nuclear export, orally bioavailable, and highly selective versus a panel of additional putative histone deacetylase (HDAC) kinases. Therefore these compounds could provide attractive tools for the further study of PKD / HDAC5 signaling.