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1262847-74-4

N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1262847-74-4 Structure

  • Basic information

    1. Product Name: N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide
    2. Synonyms: N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide
    3. CAS NO:1262847-74-4
    4. Molecular Formula:
    5. Molecular Weight: 448.522
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1262847-74-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide(1262847-74-4)
    11. EPA Substance Registry System: N-((R)-1-carbamoylethyl)-3-(5-{4-[(tetrahydropyran-4-ylamino)methyl]phenyl}isoxazol-3-yl)benzamide(1262847-74-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1262847-74-4(Hazardous Substances Data)

1262847-74-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1262847-74-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,2,8,4 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1262847-74:
(9*1)+(8*2)+(7*6)+(6*2)+(5*8)+(4*4)+(3*7)+(2*7)+(1*4)=174
174 % 10 = 4
So 1262847-74-4 is a valid CAS Registry Number.

1262847-74-4Relevant articles and documents

3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Gamber, Gabriel G.,Meredith, Erik,Zhu, Qingming,Yan, Wanlin,Rao, Chang,Capparelli, Michael,Burgis, Robin,Enyedy, Istvan,Zhang, Ji-Hu,Soldermann, Nicolas,Beattie, Kimberley,Rozhitskaya, Olga,Koch, Keith A.,Pagratis, Nikos,Hosagrahara, Vinayak,Vega, Richard B.,McKinsey, Timothy A.,Monovich, Lauren

, p. 1447 - 1451 (2011/04/16)

The synthesis and preliminary studies of the SAR of novel 3,5-diarylazole inhibitors of Protein Kinase D (PKD) are reported. Notably, optimized compounds in this class have been found to be active in cellular assays of phosphorylation-dependant HDAC5 nuclear export, orally bioavailable, and highly selective versus a panel of additional putative histone deacetylase (HDAC) kinases. Therefore these compounds could provide attractive tools for the further study of PKD / HDAC5 signaling.

ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS

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Page/Page column 149, (2011/02/24)

The present invention provides novel organic compounds of formula (I) or (Ia): which may be inhibitors of a selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example PKD-1/2/3, inhibitors of histone deacetylase (HDA

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