128455-50-5

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 

Downstream Products

• 191218-50-5 2-(4-chlorophenyl)-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 128455-58-3 4-(4-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-methyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione 
• 128455-55-0 6-Methyl-4-phenyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione 
• 128455-57-2 6-Methyl-4-phenyl-3-[1-phenyl-meth-(Z)-ylidene]-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione 

Relevant academic research and scientific papers

Electro-organic reactions part 35. Efficient carbon-oxygen bond formation in the anodic coupling of pyridopyrimidine derivatives

4-H-Pyrido[1,2-a]pyrimidine-2,4-diones (Chichibabin) derivatives, formed by condensation of 2-aminopyridines with substituted dialkylmalonates, are electroactive. In solution in CH2Cl2/CF3CO2H mixtures they are smoothly and selectively anodically coupled in high yield. The products are novel and unexpected; radical coupling at the C-3 and O-4 positions is involved and the proposed mechanism is analogous to that of oxidative phenolic coupling.