7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione

Base Information

• Chemical Name: 7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione
• CAS No.: 128455-50-5
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• DSSTox Substance ID: DTXSID301235407

Synonyms:DTXSID301235407;EU-0005238;SR-01000435785;SR-01000435785-1;7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione;128455-50-5

Chemical Property of 7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione

Chemical Property:

• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 176.058577502
• Heavy Atom Count: 13
• Complexity: 377

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CN2C(=O)CC(=O)N=C2C=C1

Technology Process of 7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione

There total 1 articles about 7-Methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) + malonic acid bis-(2,4,6-trichloro-phenyl) ester (15781-70-1) → 7-methyl-pyrido[1,2-a]pyrimidine-2,4-dione (128455-50-5)

Guidance literature:

In acetone; Heating;

DOI:10.1016/S0040-4020(01)87057-5

Reference yield: 26.0%

7-methyl-pyrido[1,2-a]pyrimidine-2,4-dione (128455-50-5) + 4-methoxy-benzaldehyde (123-11-5) → 4-(4-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-methyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione (128455-58-3)

Guidance literature:

for 0.166667h; Heating;

Reference yield: 22.0%

7-methyl-pyrido[1,2-a]pyrimidine-2,4-dione (128455-50-5) + benzaldehyde (100-52-7) → 6-Methyl-4-phenyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione (128455-55-0) + 6-Methyl-4-phenyl-3-[1-phenyl-meth-(Z)-ylidene]-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione (128455-57-2)

Guidance literature:

for 0.166667h; Heating;

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

malonic acid bis-(2,4,6-trichloro-phenyl) ester

Downstream raw materials:

6-Methyl-4-phenyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione

6-Methyl-4-phenyl-3-[1-phenyl-meth-(Z)-ylidene]-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione

4-(4-Methoxy-phenyl)-3-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-6-methyl-3H,4H-1-oxa-9,10a-diaza-anthracene-2,10-dione

2-(4-chlorophenyl)-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

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