128488-64-2Relevant academic research and scientific papers
Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes
Yu, Xiaolong,Chen, Kehao,Wang, Qi,Zhang, Wenjing,Zhu, Jin
, p. 1197 - 1200 (2018/02/09)
An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.
Synthesis of oxazoles through copper-mediated aerobic oxidative dehydrogenative annulation and oxygenation of aldehydes and amines
Xu, Zejun,Zhang, Chun,Jiao, Ning
supporting information, p. 11367 - 11370 (2013/01/15)
A fragment-assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions (see scheme). The transformation is highly efficient with the removal of six hydrogen atoms, including the cleavage of four C(sp3)-H bonds. Copyright
LITHIATED 2-METHYL-5-PHENYLOXAZOLES, FORMATION AND REACTIONS WITH ELECTROPHILES
Kashima, Choji,Arao, Hideki,Okada, Rieko
, p. 487 - 492 (2007/10/02)
The methyl group of 2-methyl-5-phenyloxazole (1) has been lithiated with lithium diisopropylamide (LDA) and the resulting lithio derivative has been reacted with electrophiles to obtain 2-alkyl-5-phenyloxazoles.
