54448-36-1

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 2-phenylethyl ester
• CAS NO: 54448-36-1
• Molecular Formula: C9H9F3O3S
• Molecular Weight: 254.23
• Mol File: 54448-36-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 2-phenylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 2-phenylethyl ester(54448-36-1)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 2-phenylethyl ester(54448-36-1)

Safety Data

• Hazardous Substances Data: 54448-36-1(Hazardous Substances Data)

Upstream product

• 17376-04-4 2-phenethyl iodide 
• 2923-28-6 silver trifluoromethanesulfonate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 60-12-8 2-phenylethanol 
• 7714-32-1 (2-(methylsulfinyl)ethyl)benzene 
• 14629-58-4 trimethyl(phenethyloxy)silane 

Downstream Products

• 15055-60-4 2-phenethyl-thiazole 
• 128488-64-2 2-(2-phenyl)ethyl-5-phenyloxazole 
• 1026536-76-4 (S)-4-Benzyloxycarbonylamino-6-methyl-3-oxo-2-phenethyl-heptanoic acid allyl ester 
• 1187947-38-1 C₁₉H₁₆N₂ 
• 1265277-62-0 (E)-methyl 4-(diethoxyphosphoryl)-2-phenethylbut-2-enoate 
• 1265277-69-7 C₁₇H₂₃N₂O₅P 
• 1265277-77-7 methyl 3-(diethoxyphosphoryl)-4-phenylcyclopent-1-enecarboxylate 
• 1260519-20-7 4-(S)-isopropyl-5,5-dimethyl-3-(2-(S)-phenethyl-5-trimethylsilanyl-pent-4-ynoyl)-oxazolidin-2-one 
• 52250-50-7 1-phenyl-3,4-dihydroisoquinoline 
• 62257-76-5 dimethylphenyl(2-phenylethyl)silane 
• 27066-35-9 (E)-1,4-diphenylbut-1-ene 

Relevant articles and documents

Straightforward Access to Thiocyanates via Dealkylative Cyanation of Sulfoxides

Thiocyanates, versatile building blocks in organic synthesis, are shown to be easily accessible via an interrupted Pummerer reaction of sulfoxides. This facile dealkylative functionalization proceeds under mild conditions through electrophilic activation of the sulfoxide partner. The resulting thiocyanate itself can serve as a handle for diversification in a straightforward one-pot procedure.

Mild Base Promoted Nucleophilic Substitution of Unactivated sp3-Carbon Electrophiles with Alkenylboronic Acids

Diverse alkenylboronic acids react smoothly with various sp3-carbon electrophiles such as unactivated alkyl triflates in the presence of mild bases such as K3PO4. The reaction protocol is very mild and thereby enables high functional group tolerance. This transition metal-free condition is orthogonal towards the classic transition metal catalyzed Suzuki coupling. (Figure presented.).

Mild copper-catalyzed fluorination of alkyl triflates with potassium fluoride

A chemoselective catalytic fluorination of alkyl triflates is described using potassium fluoride as a fluoride source. Excellent yields of the desired alkyl fluorides are obtained after one hour at 45°C using 2 mol% of the copper catalyst. With 10 mol% of the catalyst, full conversion can be achieved in less than 10 minutes at 45°C, and thus makes this procedure potentially suited for the preparation of 18F-labeled PET probes. As a result of the mild reaction conditions, only the substitution products are observed with no evidence of common side reactions, such as elimination. Reported is a preliminary study of the reaction scope, which demonstrates that the fluorination can be performed in the presence of a wide range of functional groups. Evidence suggests an unusual role of the [IPrCuOTf] catalyst as a phase-transfer catalyst and points to [IPrCuF] as the active fluorinating reagent (IPr=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene).