128495-88-5

Basic information

• Product Name: (R)-2-acetoxy-1-chloro-3-benzyloxy-2-propanol
• Synonyms: (R)-2-acetoxy-1-chloro-3-benzyloxy-2-propanol
• CAS NO: 128495-88-5
• Molecular Weight: 242.702
• Mol File: 128495-88-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-acetoxy-1-chloro-3-benzyloxy-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-acetoxy-1-chloro-3-benzyloxy-2-propanol(128495-88-5)
• EPA Substance Registry System: (R)-2-acetoxy-1-chloro-3-benzyloxy-2-propanol(128495-88-5)

Safety Data

• Hazardous Substances Data: 128495-88-5(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 13991-52-1 1-chloro-2-hydroxy-3-phenylmethoxypropane 
• 108-05-4 vinyl acetate 
• 128572-85-0 2-acetoxy-1-(benzyloxy)-3-chloropropane 

Downstream Products

• 2930-05-4 (S)-benzyl glycidyl ether 

Relevant articles and documents

A new and facile preparation of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate

A facile method for the preparation of tert-butyl (3R,5S)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate is described by a chemoenzymatic approach. In this method, one hydroxyl stereocenter at C5 is obtained with a high ee value (up to 98.0%) via an enzymatic transesterification resolution of l-chloro-3-(4-methylbenzyloxy)-2-propanol. The other hydroxyl stereocenter at C3 was built with 98.0% de, by acid-hydrolysis of a 1,3-diol-acetonide syn/anti-10. It is noteworthy that the reduction of β-hydroxy ketone 8 with sodium borohydride can be carried out smoothly in aqueous isopropyl alcohol with a high diastereomeric ratio syn/anti (drs:a) of 4.0:1.