13991-52-1

Basic information

• Product Name: 1-Benzyloxy-3-Chloro-2-Propanol
• Synonyms: 1-Benzyloxy-3-Chloro-2-Propanol;2-Benzyloxy-1-chloromethylethanol;3-(Benzyloxy)-1-chloro-2-propanol;1-(Benzyloxy)-3-chloropropan-2-ol
• CAS NO: 13991-52-1
• Molecular Formula: C₁₀H₁₃ClO₂
• Molecular Weight: 200.66202
• Mol File: 13991-52-1.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 104 °C(Press: 0.1 Torr)
• Appearance: /
• Density: 1.174±0.06 g/cm3(Predicted)
• PKA: 13.25±0.20(Predicted)
• CAS DataBase Reference: 1-Benzyloxy-3-Chloro-2-Propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-3-Chloro-2-Propanol(13991-52-1)
• EPA Substance Registry System: 1-Benzyloxy-3-Chloro-2-Propanol(13991-52-1)

Safety Data

• Hazardous Substances Data: 13991-52-1(Hazardous Substances Data)

Usage

General Description

1-Benzyloxy-3-Chloro-2-Propanol, also known as BCP, is a chemical compound with the molecular formula C10H13ClO2. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. BCP is a colorless to pale yellow liquid with a mild, pleasant odor. It is soluble in water and is flammable. This chemical is known for its ability to act as a chiral building block in the synthesis of pharmaceutical compounds, especially those with anticancer and antiviral properties. Additionally, BCP has been found to possess some antifungal and antimicrobial properties, making it a valuable compound in the development of new drugs and treatments. However, it is important to handle BCP with caution as it may cause skin and eye irritation, and prolonged exposure may have harmful effects on health.

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Relevant articles and documents

A phosphonium ylide as a visible light organophotoredox catalyst

A phosphonium ylide-based visible light organophotoredox catalyst has been designed and successfully applied to halohydrin synthesis using trichloroacetonitrile and epoxides. An oxidative quenching cycle by the ylide catalyst was established, which was confirmed by experimental mechanistic studies.

MBA-cross-linked poly(N-vinyl-2-pyrrolidone)/ferric chloride macromolecular coordination complex as a novel and recyclable Lewis acid catalyst: Synthesis, characterization, and performance toward for regioselective ring-opening alcoholysis of epoxides

A novel macromolecular-metal coordination complex, MBA-cross-linked PNVP/FeCl3 material was fabricated by immobilization of water intolerant ferric chloride onto the porous cross-linked poly(N-vinyl-2-pyrrolidone) carrier beads as a macromolecular ligand or carrier which was prepared by suspension free-radical copolymerization of N-vinyl-2-pyrrolidone (NVP) and N,N′-methylene bis-acrylamide (MBA) as a crosslinking agent in water. The obtained PNVP/FeCl3 was characterized by UV/vis and FT-IR spectroscopies, TGA, FE-SEM, EDX, and ICP techniques. This heterogenized version of ferric chloride is a convenient and safe alternative to highly water intolerant ferric chloride. The catalytic performance of (PNVP/FeCl3) as an efficient and recyclable polymeric Lewis acid catalyst was appropriately probed in the regio-and stereoselective nucleophilic ring opening of various epoxides with various alcohols in excellent yields with TOF up to 182.48 h?1 without generating any waste. The activity data indicate that this heterogeneous catalyst is very active and could be easily recovered, and reused at least six times without appreciable loss of activity indicating its stability under experimental conditions.

Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts

Preparation of vicinal halohydrins, in which copper or iron chlorides catalyze the ring-opening reaction of epoxides with visible light effectively, is described. The use of trichloroacetonitrile as a halogen source enables catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction.