128549-25-7

Upstream product

• 128549-20-2 (S)-2-Benzyloxy-2-methyl-pent-4-enoic acid 
• 128549-13-3 methyl 2-(benzyloxy)-2-methyl-4-pentenoate 
• 62696-36-0 2-hydroxy-2-methylpent-4-enoic acid methyl ester 
• 128656-58-6 (S)-2-Benzyloxy-2-methyl-pent-4-enoic acid methyl ester 

Downstream Products

• 87937-85-7 2-Benzyloxy-2-methyl-pent-4-enal 
• 128549-26-8 (S)-2-(benzyloxy)-2-methylpentane-1,5-diol 
• 136459-95-5 (S)-2-Benzyloxy-2-methyl-pent-4-enal 
• 128656-57-5 (S)-3-(2,2,4-trimethyl-1,3-dioxolan-4-yl)propan-1-ol p-toluenesulfonate 
• 136460-04-3 (R)-2-Benzyloxy-2-methyl-pent-4-enal 
• 136459-98-8 Benzoic acid (R)-2-benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5,9,10-tetramethoxy-anthracen-2-yl}-2-methyl-pent-4-enyl ester 
• 136459-99-9 Benzoic acid (R)-2-benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5-dimethoxy-9,10-dioxo-9,10-dihydro-anthracen-2-yl}-2-methyl-pent-4-enyl ester 
• 136459-97-7 (R)-2-Benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5,9,10-tetramethoxy-anthracen-2-yl}-2-methyl-pent-4-en-1-ol 
• 136460-00-9 Benzoic acid (R)-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5-dimethoxy-9,10-dioxo-9,10-dihydro-anthracen-2-yl}-2-hydroxy-2-methyl-pent-4-enyl ester 
• 136459-98-8 Benzoic acid (S)-2-benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5,9,10-tetramethoxy-anthracen-2-yl}-2-methyl-pent-4-enyl ester 
• 136459-99-9 Benzoic acid (S)-2-benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5-dimethoxy-9,10-dioxo-9,10-dihydro-anthracen-2-yl}-2-methyl-pent-4-enyl ester 
• 136459-97-7 (S)-2-Benzyloxy-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5,9,10-tetramethoxy-anthracen-2-yl}-2-methyl-pent-4-en-1-ol 
• 136460-00-9 Benzoic acid (S)-1-{6-[(2R,4R,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-tetrahydro-pyran-2-yl]-1,5-dimethoxy-9,10-dioxo-9,10-dihydro-anthracen-2-yl}-2-hydroxy-2-methyl-pent-4-enyl ester 
• 136025-69-9 (S)-(-)-4,5-dibenzyloxy-4-methyl-1-pentene 

Relevant academic research and scientific papers

A Synthesis of Natural α-Tocopherol Intermediate

(S)-(-)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanmethanol, an intermediate of natural α-tocopherol was synthesized from (S)-2-benzyloxy-2-methyl-4-pentenoic acid, which was obtained by the enzymatic hydrolysis of the corresponding racemic methyl ester.

Enzymatic Preparation of Enantiomerically Enriched Tertiary α-Benzyloxy Acid Esters. Application to the Synthesis of (S)-(-)-Frontalin

Enzymatic preparation of enantiomerically enriched tertiary α-benzyloxy acid esters is described.Enantioselective hydrolysis of the racemic esters of the formula by lipase OF (from Candida cylindracea, Meito Sangyo Co.) was succes