1285533-80-3

Upstream product

• 98-98-6 2-Picolinic acid 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 1195-45-5 para-fluorophenyl isocyanate 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 123-30-8 4-amino-phenol 
• 371-40-4 4-fluoroaniline 
• 220000-87-3 4-chloro-N-methylpicolinamide 
• 5470-22-4 4-chloropicolinic acid 

Relevant academic research and scientific papers

KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER

The present invention relates to a compound having the structure of formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X, Y, Z, R, R1, R2, R3, R4, R5, and R6 are as described herein. The present invention also relates to compositions containing the compound having the structure of formula (I), and a method of treating cancer in a subject.

Synthesis of aryl urea derivatives from aryl amines and aryl isocyanates

The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl] amino]phenoxy]-N-methylpyridine-2- carboxamide] having potential antiproliferative activity.