128563-80-4Relevant academic research and scientific papers
The Synthesis of Novel Benzomorphan Analogues: A New Intramolecular Acid-catalysed Aldol Route to Benzannelated Bicyclononane Derivatives. X-Ray Molecular Structure of 8-Hydroxy-1-methoxytricyclo2,7>trideca-2,4,6-trien-10-one
Taylor, Richard J. K.,Turner, Stephen M.,Horwell, David C.,Howarth, Oliver W.,Mahon, Mary F.,Molloy, Kieran C.
, p. 2145 - 2150 (2007/10/02)
Novel benzomorphan analogues are described in which the piperidine ring is replaced by an aminocyclohexane ring.The key synthetic intermediate, benzannelated bicyclononane derivative (12), is prepared by an efficient three-step synthetic route base
A New Intramolecular Aldol based Route to Benzannelated Bicyclononane Derivatives
Taylor, Richard J. K.,Turner, Stephen M.,Horwell, David C.
, p. 406 - 408 (2007/10/02)
A synthetic route to the title compounds is described based on the addition of 2-lithiobenzaldehyde ethylene ketal to cyclohexane-1,4-dione ethylene ketal followed by acid-catalysed deprotection and in situ intramolecular stereospecific aldol cyclisation, which gives 8-hydroxy-1-methoxytricyclo2,7>trideca-2,4,6-trien-10-one (1a); the synthetic potential of the methodology for preparation of various derivatives is described.
