1285694-85-0Relevant academic research and scientific papers
Decarboxylative cyclization of amino acids towards the Regioselective synthesis of 2,4-diarylpyridines via relay Fe(III)/In(III)-catalysis
Gujjarappa, Raghuram,Vodnala, Nagaraju,Malakar, Chandi C.
, (2020)
A competent relay Fe(III)-/In(III)-catalyzed decarboxylative cyclization of amino acids has been devised towards the exclusive preparation of 2,4-diarylpyridines. The efficacy of the developed conditions drives the reaction towards selective formation of 2,4-diarylpyridines over other pyridine derivatives. The described protocol showed good functional group tolerance with moderate to good yields of products.
Pd-Catalyzed Decarboxylation and Dual C(sp3)-H Functionalization Protocols for the Synthesis of 2,4-Diarylpyridines
Gujjarappa, Raghuram,Vodnala, Nagaraju,Kumar, Mohan,Malakar, Chandi C.
, p. 5005 - 5020 (2019/04/25)
The Pd-catalyzed decarboxylation and dual C(sp3)-H bond functionalization approaches have been described for the preparation of symmetrical and unsymmetrical 2,4-diarylpyridines. The developed transformations were realized using nonactivated aromatic ketones and amino acids as C-N sources. The efficacy of the catalyst and reagent combination drives the transformation toward the formation of desired products with high yields and selectivity. The described reaction conditions have seduced the self-reaction of phenylalanine via [2 + 2 + 2] cycloaddition and minimized the formation of 3,5-phenylpyridine as a side product, whereas using glycine as a C-N source, the corresponding 2,6-diarylpyridines were formed as minor products.
Simple selective synthesis of 2,4- and 2,6-diarylpyridines through metal-free cyclocondensation of aromatic ketones with ammonium acetate
Liu, Jin,Wang, Chuanxin,Wu, Liansheng,Liang, Fen,Huang, Guosheng
experimental part, p. 4228 - 4234 (2011/02/22)
A simple and selective one-pot synthesis of 2,4- and 2,6-diarylpyridines through the cyclocondensation reaction of aromatic ketones with ammonium acetate has been developed. The procedure is metal-free, convenient, and efficient, and the substrates are re
