1286264-62-7

Basic information

• Product Name: N²-{2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide
• CAS NO: 1286264-62-7
• Molecular Weight: 604.577
• Mol File: 1286264-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N²-{2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N²-{2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide(1286264-62-7)
• EPA Substance Registry System: N²-{2-[(1-acetylpiperidin-4-yl)(methyl)amino]-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide(1286264-62-7)

Safety Data

• Hazardous Substances Data: 1286264-62-7(Hazardous Substances Data)

Upstream product

• 1286264-61-6 N²-{2-{[1-(tert-butoxycarbonyl)piperidin-4-yl](methyl)amino}-2-oxoethyl}-N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 121-27-7 2-(4'-chlorophenoxy)-5-chloro-aniline 
• 135-12-6 4-chloro-1-(4-chlorophenoxy)-2-nitrobenzene 
• 106-48-9 4-chloro-phenol 
• 89-61-2 2,5-dichloronitrobenzene 
• 7154-73-6 1-(2-aminoethyl)pyrrolidine 

Relevant articles and documents

Discovery and structural analyses of S-adenosyl-l-homocysteine hydrolase inhibitors based on non-adenosine analogs

Optimization of a new series of S-adenosyl-l-homocysteine hydrolase (AdoHcyase) inhibitors based on non-adenosine analogs led to very potent compounds 14n, 18a, and 18b with IC50 values of 13 ± 3, 5.0 ± 2.0, and 8.5 ± 3.1 nM, respectively. An X-ray crystal structure of AdoHcyase with NAD+ and 18a showed a novel open form co-crystal structure. 18a in the co-crystals formed intramolecular eight membered ring hydrogen bond formations. A single crystal X-ray structure of 14n also showed an intramolecular eight-membered ring hydrogen bond interaction.