128640-07-3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 66985-48-6 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 80096-48-6 (+/-)-4-Methoxycathinone 
• 120390-76-3 (R)-(+)-α-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzeneacetonitrile 
• 120390-74-1 (R)-2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 33646-40-1 4-methoxymandelonitrile 
• 742095-36-9 (RS)-2-trifluoroacetamido-1-(4-methoxyphenyl)-1-propanone 
• 42416-75-1 4'-methoxy-2-aminopropiophenone hydrochloride 
• 55275-60-0 N-[(1RS,2SR)-2-hydroxy-2-(4-methoxy-phenyl)-1-methyl-ethyl]-benzamide 

Downstream Products

• 94621-50-8 N-[5c-(4-methoxy-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-maleimide 
• 103990-74-5 3-(4-Methyl-4-ethyl-2,6-dioxo-piperidinomethyl)-4-methyl-5-(4-methoxy-phenyl)-oxazolidin 
• 93538-43-3 N-[5c-(4-methoxy-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-succinimide 
• 94545-88-7 N-[5c-(4-methoxy-phenyl)-4r-methyl-oxazolidin-3-ylmethyl]-phthalimide 
• 99985-91-8 cis-5-(4-methoxy-phenyl)-4-methyl-oxazolidine 

Relevant academic research and scientific papers

MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position

Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and β-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the arylalkylamine scaffold.

(-)-ritodrine, therapeutic compositions and use, and method of preparation

(-)-Ritodrine, that is (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-propanol or a salt thereof substantially free from the (+)-isomer is disclosed. The compound has a strong suppressive effect on uterine contraction in comparison with (±)-ritodrine and (+)-ritodrine and has the same level of toxicity as these compounds, so that it can be used as a therapeutic agent of threatened premature birth and threatened abortion as well as a therapeutic agent of dysmenorrhea having a high safety.

Applications of Optically Active Aryl Cyanohydrins in the Synthesis of α-Hydroxy Aldehydes, α-Hydroxy Ketones and β-Hydroxy Amines

Cyanohydrins, prepared in high optical purity from aryl aldehydes, have been converted into α-hydroxy aldehydes, α-hydroxy ketones and β-hydroxy amines without any racemization and frequently with good stereoselectivity for the erythro-diastereoisomer (>90percent) at the newly introduced stereogenic centre.