128666-81-9

Upstream product

• 70638-53-8 4‐oxo‐2‐thioxo‐6‐(p-tolyl)‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile 
• 74-88-4 methyl iodide 
• 104-87-0 4-methyl-benzaldehyde 
• 14527-26-5 2-methylisothiourea sulphate 
• 105-56-6 ethyl 2-cyanoacetate 
• 147895-43-0 S-methylisothiourea hemisulphate 

Downstream Products

• 131890-43-2 1-Methyl-2-methylsulfanyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidine-5-carbonitrile 
• 1338916-89-4 1-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-5-cyano-6-(4-methylphenyl)-2-(methylthio)pyrimidin-4(1H)-one 
• 1338916-95-2 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-cyano-6-(4-methylphenyl)-2-(methylthio)-pyrimidin-4(1H)-one 
• 1338917-01-3 1-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-5-cyano-6-(4-methylphenyl)-2-(methylthio)-pyrimidin-4(1H)-one 
• 131890-63-6 5-Amino-1-[5-cyano-4-(3-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 131890-60-3 5-Amino-1-(5-cyano-1-methyl-6-oxo-4-p-tolyl-1,6-dihydro-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 131890-71-6 5-cyano-3-methyl-6-(4-methylphenyl)-2-piperonalhydrazino-3,4-dihydropyrimidin-4-one 
• 131890-68-1 6-cyano-3-mercapto-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one 
• 131890-50-1 2-anilino-5-cyano-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one 
• 131890-69-2 2-acetylhydrazino-5-cyano-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one 
• 131890-67-0 6-cyano-8-methyl-5-(4-methylphenyl)-1,2,4-triazolo<3,4-b>pyrimidin-4-one 
• 131890-53-4 5-cyano-2-hydrazino-3-methyl-6-(4-methylphenyl)-3,4-dihydropyrimidin-4-one 
• 128640-74-4 4-chloro-6-(4-methylphenyl)-2-methylthiopyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues

New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different

Vasoactive thiomethyl-pyrimidines: Promising drug candidates with vascular activity

Pyrimidines and their derivatives are present in various biologically active molecules. Most of the synthetic methods employed to achieve the pyrimidinone ring consist of two stages: The synthesis of a Michael intermediate from an aldehyde and an "active

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids

Abstract A series of hybrids comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of py

An efficient and facile synthesis of inhibitors for hepatitis C viral and anti-SARS agents: 4-aryl-5-cyano-1,6-dihydro-2-thiouracils

One-pot, multicomponent reaction for the synthesis of 4-aryl-5-cyano-1,6- dihydro-2-thiouracils via three-component from aromatic aldehydes, ethyl 2-cyanoacetate and S-benzylisothiourea hydrochloride (methyl carbamimidothioate sulfate) under methanol is d

Synthesis and antiviral activity of new substituted pyrimidine glycosides

A number of N-substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral activities.

A one pot regioselective synthesis of new functionalized derivatives of [1,2,41 Triazolo [4,3-α] pyrimidin-5 (lH)-one

REACTION of 5-cyano-6-aryl-2-thiouracil 1A-C or its methylthio derivatives 2A-C with hydrazonoyl chlorides 3a-h led to the formation of 7-aryl-6-cyano-1,2,4-triazolo[4,3-a] pyrmidin-5(111)-one derivatives 8. The mechanism and the regioselectivity of the studied reactions were discussed with the help of the given X-ray crystallographic data .

Glycosylation of 2-thiouracil derivatives. A synthetic approach to 3- glycosyl-2,4-dioxypyrimidines

Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a- h. However, their deacetylation with ammonia in methanol caused a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h.