1286694-34-5

Upstream product

• 100-52-7 benzaldehyde 
• 1286694-32-3 (Z)-2-fluoro-1-phenyl-2-(phenylsulfonyl)vinyl benzoate 
• 688-73-3 tri-n-butyl-tin hydride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1456623-34-9 (Z)-2-fluoro-2-iodo-1-phenylvinyl benzoate 
• 1456623-36-1 (E)-2-fluoro-3-oxo-1,3-diphenylprop-1-en-1-yl benzoate 

Relevant academic research and scientific papers

Highly stereoselective and one-pot synthesis of tetra-substituted monofluoroalkenes with aldehydes and fluorobis(phenylsulfonyl)methane

A highly stereoselective synthesis of tetrasubstituted monofluoroalkenes with aldehydes and fluorobis(phenylsulfonyl)methane (FBSM) in one pot has been developed. The reaction was amenable to para- and meta-substituted aryl aldehydes, 2-naphthaldehyde, and cinnamaldehyde, giving phenylsulfonyl- substituted monofluoroalkenes in 40%-86% yields with 98/2-99/1 Z/E ratios. The presence of the sulfonyl group enables the further transformation of the products into more useful monofluoroalkenes. Highly stereoselective and one-pot synthesis of tetrasubstituted monofluoroalkenes with fluorobis(phenylsulfonyl) methane (FBSM) as the fluoroolefination reagent has been developed. This protocol is amenable to the transformation of non-enolizable aldehydes with less sterically demanding substituents. For enolizable aldehydes and sterically hindered aromatic aldehydes, the reaction furnishes carbonyl addition products. Copyright