1286694-39-0Relevant academic research and scientific papers
Nucleophilic fluoromethylation of aldehydes with fluorobis(phenylsulfonyl) methane: The importance of strong Li-O coordination and fluorine substitution for C-C bond formation
Shen, Xiao,Zhang, Laijun,Zhao, Yanchuan,Zhu, Lingui,Li, Guangyu,Hu, Jinbo
supporting information; experimental part, p. 2588 - 2592 (2011/04/25)
The tighter, the better! Fluorobis(phenylsulfonyl)methane reacts readily with aldehydes to give addition products in excellent yields (see scheme; LiHMDS=lithium hexamethyldisilazide), which is in sharp contrast to previous findings. Both strong Li-O coordination at low temperature and fluorine substitution play important roles in successful C-C bond formation. Copyright
