1286754-91-3Relevant academic research and scientific papers
Direct C-H photoarylation of diazines using aryldiazonium salts and visible-light
Silva, Rodrigo C.,Villela, Lucas F.,Brocksom, Timothy J.,De Oliveira, Kleber T.
, p. 31115 - 31122 (2020/09/23)
In this study, direct C-H photoarylation of pyrazine with aryldiazonium salts under visible-light irradiation (blue-LEDs) is described, and additional examples including photoarylations of pyrimidine and pyridazine are also covered. The corresponding aryl-diazines were prepared in yields up to 84% only by mixing and irradiating the reaction with no need for an additional photocatalyst. We demonstrate the efficacy of this protocol by the scope with electron-donor, -neutral, and -withdrawing groups attached at the ortho, meta, and para positions of the aryldiazonium salts; the results are better than those reported for ruthenium-complex mediated photoarylations. Additionally, we demonstrate the robustness of this methodology with a 5 mmol scaled-up experiment. Mechanistic studies were carried out giving support to the proposal of a photocatalyzed approach by an electron donor-acceptor (EDA) complex, also highlighting the crucial role that solvents play in the formation of the EDA complex. This journal is
Piperazine derivatives and the use thereof as medicament
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Paragraph 0237, (2015/04/21)
The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).
PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT
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Page/Page column 52; 53, (2015/05/05)
The present inventions relate to substituted piperazine derivatives of general formula (I) and to the manufacture of said compounds, pharmaceutical compositions comprising a compound according to general formula (I), and the use of said compounds for the treatment of various medical conditions related to glycine transporter-1 (GlyT1).
Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy
Viswanadham, K. K. Durga Rao,Prathap Reddy, Muktapuram,Sathyanarayana, Pochampalli,Ravi, Owk,Kant, Ruchir,Bathula, Surendar Reddy
, p. 13517 - 13520 (2015/01/09)
An efficient iodine-mediated oxidative annulation of aryl acetylenes-arylethenes-aromatic ketones with 1,2-diamines for the synthesis of pyrazines and regioselective synthesis of quinoxalines is presented. A multipathway coupled domino approach has been developed for the one-pot synthesis of 1,4-diazines with high functional group compatibility.
Pd(OAc)2-catalyzed regioselective aromatic C-H bond fluorination
Lou, Shao-Jie,Xu, Dan-Qian,Xia, Ai-Bao,Wang, Yi-Feng,Liu, Yun-Kui,Du, Xiao-Hua,Xu, Zhen-Yuan
supporting information, p. 6218 - 6220 (2013/07/25)
A novel Pd(OAc)2-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e.g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives. A Pd(ii/iv) catalytic cycle was proposed based on the ESI-MS/MS studies. The Royal Society of Chemistry 2013.
