128741-83-3

Basic information

• Product Name: (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene
• Synonyms: (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene
• CAS NO: 128741-83-3
• Molecular Weight: 292.494
• Mol File: 128741-83-3.mol

Chemical Properties

• CAS DataBase Reference: (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene(CAS DataBase Reference)
• NIST Chemistry Reference: (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene(128741-83-3)
• EPA Substance Registry System: (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene(128741-83-3)

Safety Data

• Hazardous Substances Data: 128741-83-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 233666-22-3 1-O-tert-butyldimethylsilyl-2-O-methanesulfonyloxy-ethane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 102229-10-7 2-(tert-butyldimethylsilyloxy)ethanol 
• 519013-64-0 5-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)sulfanyl]-1-phenyl-1H-tetrazole 
• 81028-03-7 (Z)-4-benzyloxy-but-2-en-1-ol 

Downstream Products

• 381221-85-8 1-(3-Benzyloxymethyl-2,2-difluoro-cyclopropylmethylselanyl)-2-nitro-benzene 
• 196495-45-1 2-benzyloxymethyl-3,3-difluoro-1-methylenecyclopropane 
• 6306-73-6 1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 81028-03-7 (Z)-4-benzyloxy-but-2-en-1-ol 

Relevant articles and documents

Efficient and stereoselective synthesis of allylic ethers and alcohols

(Chemical Equation Presented) A short and efficient synthesis of allylic TBS ethers and allylic alcohols has been developed, based upon a unique Kocienski-Julia olefination reaction. Allylic alcohols and allylic ethers are obtained in good to excellent yields and with high (E)-selectivity. The conditions are mild and the procedure is broadly applicable.

Synthesis of new nucleoside analogues comprising a geminal difluorocyclopropane moiety as potential antiviral/antitumor agents

Geminal difluorocyclopropane analogues of nucleosides 7a - 7e were synthesized. Compounds 7a and 7c - 7e were obtained by alkylation of nucleic acid bases or their appropriate precursors with (cis)-1- benzyloxymethyl-2-bromomethyl-3,3-difluorocyclopropane (8). Analogue 7b was prepared by hydrolysis of 2-amino-6-chloropurine derivative 7e. Compounds 7a - 7d did not exhibit any antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1 or antitumor effects against murine leukemia L1210, mouse tumors PO3 or C38 and human tumor H15.

Regiochemical control of the ring opening of 1:2-epoxides by means of chelating processes. 10. Synthesis and ring opening reactions of mono- and difunctionalized cis and trans aliphatic oxirane systems

The regiochemical outcome of the ring opening of 1:2-epoxides through chelation processes assisted by metal ions, was verified in mono- and difunctionalized aliphatic oxirane systems bearing the heterofunctionality (OR) in an homoallylic and/or allylic relationship to the oxirane ring. The effect of the distance of the OR functionality from the oxirane ring and of the type of protective group on the regiochemical outcome of these systems is examined. In some cases, the use of LiClO4 or Mg(ClO4)2 as the promoting metal salt makes it possible the obtainment of a nice regioalternating process.