128746-84-9Relevant academic research and scientific papers
REACTION OF α-ACETYLBUTYROLACTONE WITH AMINES
Malawska, Barbara,Gorczyca, Maria
, p. 63 - 68 (2007/10/02)
The reaction of α-acetylbutyrolactone and its ethylene ketal derivative with primary amines were investigated.Depending on the reaction conditions derivatives of butyrolactone (-) or urea (, ) or γ-hydroxybutyric acid (-) were obtained.The cyclisation reaction of γ-hydroxybutyric acid derivatives (-) to the corresponding 1,3-disubstituted pyrrolidinone-2 were also examined.Keywords: α-acetylbutyrolactone, γ-hydroxybutyric acid, elemental and spectral analysis, cyclization reaction
Synthesis and crystal and molecular structure of new N-substituted γ-hydroxybutyramides
Malawska, B.,Gorczyca, M.,Wieczorek, W.
, p. 139 - 144 (2007/10/02)
The N-(2-phenylethyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (II) and the N-(p-methoxybenzyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (III) have been synthesized and the crystal structure of III has been solved.Compound III, C16H23O5N, crystallizes in the monoclinic space group P21/c with a = 12.572(2), b = 11.149(2), c = 12.317(2) Angstroem and β = 106.53(1) deg.The structure was solved by direct methods, and refined by full-matrix least squares to give R = 0.040 (Rw = 0.047) for 2004 intensities.The dioxolane ringhas a deformed half-chair conformation.
