128757-43-7Relevant academic research and scientific papers
Enantioselective addition of diorganozincs to aldehydes catalyzed by β-amino alcohols
Noyori, R.,Suga, S.,Kawai, K.,Okada, S.,Kitamura, M.,et al.
, p. 19 - 37 (2007/10/02)
Nucleophilic addition of dialkylzincs to aldehydes in hydrocarbon solvents is markedly accelerated by the presence of a catalytic amount of a β-dialkylamino alcohol.Use of certain sterically constrained chiral amino alcohols such as 3-exo-(dimethylamino)isoborneol or 1-t-butyl-2-piperidinoethanol effects highly enantioselective catalysis giving secondary alcohols in up to 99percent ee.Dimethyl-, diethyl-, di-n-butyl-, and di-n-pentyl-zincs have been employed for the alkylation of substituted benzaldehydes and some olefinic or aliphatic aldehydes.Configurational correlation between the chiral auxiliary and alkylation products is discussed.
