128863-85-4Relevant academic research and scientific papers
Experimental and theoretical rearrangement of N-acyl-2,2- dimethylaziridines in acidic medium
Mhiri, Madiha Kamoun,Aboumessaad, Firas,Efrit, Mohamed Lotfi,Arfaoui, Youssef,Besbes, Néji
, p. 235 - 245 (2016)
The acid isomerization of N-acyl-2,2-dimethylaziridines 1 in concentrated sulfuric acid at room temperature leads to oxazolines 2 but the neutral hydrolysis of 1 in pure water at room temperature leads to amidoalcohols 3. However, the use of aqueous solutions of H2SO4 at different concentrations at room temperature leads to a mixture of oxazolines 2, amidoalcohols 3 and allylamides 4 with yields depending on the acidity of the medium and the nature of the acyl group. A mechanism has been suggested to explain the formation of these three products. DFT calculations employing the Gaussian 09 program with DFT/B3LYP methods and 6-311++G(2d,2p) basis set were carried out which gave the most stable geometry as well as their atomic charge distributions of compounds 1-4. [Figure not available: see fulltext.]
Isomerisation catalysee par le gel de silice et L'argile activee de N-Acyl-2,2-Dimethylaziridines: Approche mecanistique
Besbes, Neji,Jellali, Houyem,Pale, Patrick,Efrit, Mohamed Lotfi,Srasra, Ezzeddine
experimental part, p. 883 - 889 (2010/07/05)
Silica gel and activated clay, behaving as Lewis acids, reacted with N-acyl-2,2-dimethylaziridines 1 to lead to pentacoordinated aziridinium silicate ions. The regiospecific ring opening on the CMe2 carbon side of the intermediate I involves, after remova
