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Upstream product

• 63093-41-4 ethyl 4-pentynoate 
• 696-62-8 para-iodoanisole 
• 4181-11-7 3-hex-1-enylamine 
• 137742-44-0 5-<4-methoxyphenyl>-4-pentynoic acid 
• 729580-61-4 ethyl 5-(4-methoxylphenyl)-4-pentynoate 

Relevant academic research and scientific papers

Rhodium-Catalyzed Domino Hydroformylation/Double-Cyclization Reaction of Arylacetylenecarboxamides: Diastereoselectivity Studies and Application in the Synthesis of 1-Azabicyclo[x.y.0]alkanes

A domino method for the rapid syntheses of 1-azabicyclo[x.y.0]alkane scaffolds, such as indolizidines, quinolizidines, decahydropyridoazepines, and their derivatives, has been developed. This strategy involved a rhodium-catalyzed hydroformylation of allyl

Alkyne-mediated domino hydroformylation/double cyclization: Mechanistic insight and synthesis of (±)-tashiromine

A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.