729580-61-4

Upstream product

• 768-60-5 4-methoxyphenylacetylen 
• 140-88-5 ethyl acrylate 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 6089-09-4 4-pentynoic acid 
• 63093-41-4 ethyl 4-pentynoate 
• 696-62-8 para-iodoanisole 

Downstream Products

• 1289154-49-9 (E)-8-(α-acetyloxy-4'-methoxybenzylidenyl)-5-oxoindolizidine 
• 1289154-41-1 N-allyl-5-(4-methoxyphenyl)-4-pentynamide 
• 1314451-10-9 2-(4-(4-methoxyphenyl)but-3-ynyl)-1H-benzo[d]imidazole 
• 1314451-28-9 C₁₈H₁₅IN₂O 
• 1289154-45-5 N-(1-hexen-3-yl)-5-(4-methoxyphenyl)-4-pentynamide 
• 24962-85-4 (+/-)-5-(4-methoxyphenylcarbonyl)dihydrofuran-2(3H)-one 
• 928768-39-2 N-benzyl-5-(4-methoxyphenyl)-pent-4-ynamide 
• 137742-44-0 5-<4-methoxyphenyl>-4-pentynoic acid 

Relevant academic research and scientific papers

Copper(II)-Mediated Ring Opening/Alkynylation of Tertiary Cyclopropanols by Using Nonmodified Terminal Alkynes

The copper(II)-mediated ring opening/alkynylation of cyclopropanol by employing inexpensive and commercially available terminal alkyne is developed. The reactions proceeded efficiently to afford synthetically useful alk-4-yn-1-ones in moderate to good yie

Method for preparing 4-acetylenic ketone/ester compound and application thereof

The invention relates to a method for preparing a 4-acetylenic ketone/ester compound and an application thereof, and particularly provides a preparation method of a copper-mediated 4-acetylenic ketone/ester compound. The process is mild in reaction conditions and good in yield, and the compound has strong functional group tolerance and good compatibility.

Direct conjugate addition of alkynes with α,β-unsaturated carbonyl compounds catalyzed by NCN-pincer Ru complexes

NCN-pincer Ru-complexes containing bis(oxazolinyl)phenyl ligands serve as suitable catalysts in the direct conjugate additions of α,β- unsaturated carbonyl compounds, including ketones, esters, and amides, as well as vinylphosphonates, giving various β-alkynyl carbonyl and phosphonate compounds. A bis(oxazolinyl)phenyl (phebox)-Ru complex also catalyzes the asymmetric conjugate addition of an alkyne with a β-substituted, α,β-unsaturated ketone to produce a chiral β-alkynyl ketone. Copyright

Indium(III) chloride catalyzed conjugate addition reaction of alkynylsilanes to acrylate esters

A novel and efficient procedure for the synthesis of δ,γ- alkynyl esters by the conjugate addition of alkynylsilanes to acrylate esters in the presence of a catalytic amount of indium(III) chloride has been developed. This method provides a rapid and efficient access to substituted δ,γ-alkynyl esters.

Alkyne-mediated domino hydroformylation/double cyclization: Mechanistic insight and synthesis of (±)-tashiromine

A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.

An effective synthetic entry to fused benzimidazoles via iodocyclization

A protocol for the synthesis of the fused heterocyclic polycyclic compounds pyrrole[1,2-a]benzimidazoles, piperidine[1,2-a]benzimidazoles and oxa-fused benzimidazoles using iodine and silver nitrate by an exo-dig or endo-dig cyclization pathway at room te

Intramolecular PIFA-mediated alkyne amidation and carboxylation reaction

(Chemical Equation Presented) The hypervalent iodine reagent PIFA promotes the intramolecular electrophilic cyclization of easily accessible alkynylamides and alkynyl carboxylic acids, leading to the formation of pyrrolidinone and lactone skeletons, respe

Ruthenium/halide catalytic system for C-C bond forming reaction between alkynes and unsaturated carbonyl compounds

A ruthenium complex [triruthenium dodecacarbonyl, Ru3(CO) 12] in the presence of bis(triphenylphosphine)iminium chloride ([PPN]Cl) catalyzes the conjugate addition of terminal alkynes to alkyl acrylates to give high yields of γ,δ-alkynyl esters. On the other hand, the linear codimerization reaction of terminal alkynes with alkyl acrylates proceeds in the presence of a catalytic amount of Ru 3(CO)12 and lithium iodide to give the corresponding conjugate dienes. These two different types of catalytic carbon-carbon bond forming reactions are controlled only by the nature of halide ions, either a chloride or an iodide, with other conditions being kept almost the same.

Ruthenium/chloride catalytic system for conjugate addition of terminal alkynes to acrylate esters

The addition of terminal alkynes to acrylate esters in the presence of a ruthenium catalyst and chloride sources proceeds to give the corresponding γ,δ-alkynyl esters in good yields.