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1289206-92-3

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1289206-92-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1289206-92-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,9,2,0 and 6 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1289206-92:
(9*1)+(8*2)+(7*8)+(6*9)+(5*2)+(4*0)+(3*6)+(2*9)+(1*2)=183
183 % 10 = 3
So 1289206-92-3 is a valid CAS Registry Number.

1289206-92-3Downstream Products

1289206-92-3Relevant academic research and scientific papers

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

Yan, Xuelei,Wang, Zhulun,Sudom, Athena,Cardozo, Mario,Degraffenreid, Michael,Di, Yongmei,Fan, Pingchen,He, Xiao,Jaen, Juan C.,Labelle, Marc,Liu, Jinsong,Ma, Ji,McMinn, Dustin,Miao, Shichang,Sun, Daqing,Tang, Liang,Tu, Hua,Ursu, Stefania,Walker, Nigel,Ye, Qiuping,Powers, Jay P.

, p. 7071 - 7075 (2010)

In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.

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