57302-39-3

Usage

Properties

Tertiary alcohol, molecular weight of 244.36 g/mol

Family

Thioether alcohol

Uses

Intermediate in pharmaceutical synthesis, potential applications in organic chemistry industries

Upstream product

• 610-94-6 2-bromobenzoic acid methyl ester 
• 108-98-5 thiophenol 
• 676-58-4 methylmagnesium chloride 
• 67373-13-1 2-phenylsulfanyl-benzoic acid methyl ester 
• 917-64-6 methyl magnesium iodide 
• 1527-13-5 2-Phenylthiobenzoesaeureethylester 

Downstream Products

• 19019-10-4 9,9-dimethyl-9H-thioxanthene 
• 1289206-92-3 C₁₇H₁₈O₂S 
• 150192-72-6 2,7-Dibenzoyl-9,9-dimethylthioxanthen 

Relevant academic research and scientific papers

Noble Compound Exhibiting Thermally Activated Delayed Fluorescence and Organic Light-Emitting device Using the Same

The present invention relates to a novel compound which due to having little difference between a singlet energy state and a triplet energy state, exhibits a thermally activated delayed fluorescence by reverse intersystem crossing when heat is applied, that generates the singlet energy state from the triplet energy state; and to an organic light-emitting device which applies the same to a dopant of an organic light-emitting layer. Specifically, the present invention relates to a compound represented by chemical formula 1; and to an organic light-emitting device which applies the same to a dopant of an organic light-emitting layer, wherein in the chemical formula 1, R_1 and R_2 may be identical or different from each other, and are a pyridoindole group, a phenyl group, a carbazole group, a 9,9-dimethyl-9,10-dihydroacridine group, a 10H-phenothiazine group, or 10H-phenoxazine group, and R_3 is a methyl or phenyl group.COPYRIGHT KIPO 2017

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors

In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.

Chalcogeno-Substituted Bis-triphenylmethylium Ions of the Inverse Malachite Green Type

The longest wavelength VIS absorptions of the deeply colored CF3CO2H solutions of the 4,4'-chalcogenobis-(triphenylmethylium) ions 4(++), Y2 (Y = O, S, Se, Te) resemble closely those of the corresponding monocationic 4-arylchalcogenotriphenylmethylium systems 5(1+), ArYC6H4C(1+)(C6H5)2, and not those of the structurally directly related 4,4'-bis(arylchalcogeno)triphenylmethylium ions 3(1+), C6H5C(1+)(C6H4YAr)2.This is in striking contrast to the results obtained previously for analogous nitrogen systems, where "inverse", 2(++), RN, and "conventional" malachite green systems 1(+), (Ar2NC6H4)2C(1+)R, yield almost identical λmax values.A rationalization of these observations can be achieved based on the assumption of largely delocalized dications 2(++) versus more or less orthogonal "double monocationic" systems 4B(++), separated due to torsional twist.Whereas the formal push-pull systems 6(+), ArSC6H4YC6H4C(1+)(C6H5)2 (Y = O, S, Se) behaved practically like the corresponding standard systems 5(+), the mono- and bis-triphenylmethylthio-substituted dibenzofuran, dibenzothiophene and thioxanthene derivatives 8(+), 9(++), 10(+) and 11(++) displayed hypsochromic shifts of their color bands relative to their noncyclic analogues which are only partly in accordance with predictions based on a simple frontier orbital Hueckel model.The 1H and 13C NMR spectra of all these cationic species comply with their respective charges. +"--"+ Dyes, Chalcogeno-bis-trityliumions, VIS Spectra, NMR Spectra