1289207-30-2

Basic information

• Product Name: 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile
• Synonyms: 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile;1H-Pyrrole-2-carbonitrile, 4-bromo-1-methyl-;EOS-61144
• CAS NO: 1289207-30-2
• Molecular Formula: C₆H₅BrN₂
• Molecular Weight: 185.03
• Mol File: 1289207-30-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile(1289207-30-2)
• EPA Substance Registry System: 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile(1289207-30-2)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 1289207-30-2(Hazardous Substances Data)

Usage

General Description

4-bromo-1-methyl-1H-pyrrole-2-carbonitrile is a chemical compound with the formula C6H5BrN2. It is a pyrrole derivative with a bromine atom and a methyl group attached to the pyrrole ring, as well as a carbonitrile functional group. 4-bromo-1-methyl-1H-pyrrole-2-carbonitrile is commonly used in organic synthesis and pharmaceutical research as a building block for more complex molecules. It has potential applications in the development of drugs for various medical conditions due to its unique structure and reactivity. Additionally, it is important to handle this chemical with care, as it may present health hazards and should be used in a controlled laboratory environment.

Upstream product

• 4513-94-4 1H-pyrrole-2-carbonitrile 
• 34884-10-1 1-methyl-1H-pyrrole-2-carbonitrile 

Downstream Products

• 1289207-31-3 2-cyano-4-(4-methoxyphenyl)-1-methylpyrrole 
• 1289206-26-3 5-bromo-3-(2,4-dimethylfuran-3-yl)-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide 
• 1289207-32-4 5-bromo-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile 
• 1289207-33-5 5-bromo-3-iodo-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile 
• 1289207-35-7 5-bromo-4-(4-hydroxyphenyl)-3-iodo-1-methyl-1H-pyrrole-2-carbonitrile 
• 1289207-36-8 5-bromo-3-(2,4-dimethylfuran-3-yl)-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile 
• 1799628-14-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carbonitrile 

Relevant articles and documents

INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.