128923-99-9

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

This describes the arrangement of atoms and functional groups in the compound, which gives it its unique properties.

Explanation

These are the specific functional groups present in the compound that contribute to its chemical reactivity and properties.

Explanation

The compound is used in these fields due to its unique chemical properties, which make it a valuable building block for the synthesis of more complex molecules.

Explanation

The compound serves as a starting material or intermediate in the synthesis of various pharmaceuticals, dyes, and other organic compounds.

Explanation

The compound has the potential to cause skin and eye irritation, which is why it should be handled with care and in accordance with safety guidelines.

Explanation

Due to its potential health hazards, it is important to take necessary precautions when working with 1-(benzyloxy)-3-bromo-5-nitrobenzene, such as wearing appropriate personal protective equipment (PPE) and working in a well-ventilated area.

Chemical structure

Nitrobenzene derivative with a benzyl ether and a bromine atom attached to the benzene ring

Functional groups

Nitro group (-NO2), benzyl ether (-OCH2Ph), and bromine atom (-Br)

Application

Organic synthesis and medicinal chemistry research

Utilization

Production of pharmaceuticals, dyes, and other organic compounds

Health hazards

Skin and eye irritation

Safety precautions

Handle with care and follow safety guidelines

Upstream product

• 18242-39-2 3,5-dinitrobromobenzene 
• 100-51-6 benzyl alcohol 
• 116632-23-6 3-bromo-5-nitro-phenol 
• 100-39-0 benzyl bromide 
• 121-88-0 5-Nitro-2-aminophenol 
• 915156-09-1 2-amino-3-bromo-5-nitro-phenol 

Downstream Products

• 1000289-63-3 3-bromo-5-phenylmethoxyaniline 
• 1000289-64-4 N-[(3-benzyloxy-5-bromophenyl)carbamothioyl]benzamide 
• 1000289-65-5 1-(3-(benzyloxy)-5-bromophenyl)thiourea 
• 1000289-66-6 5-benzyloxy-7-bromo-1,3-benzothiazol-2-amine 
• 1000289-67-7 1-(5-benzyloxy-7-bromo-1,3-benzothiazol-2-yl)-3-ethyl-urea 
• 1372548-00-9 1-[5-benzyloxy-7-(2-pyridyl)-1,3-benzothiazol-2-yl]-3-ethyl-urea 
• 1372548-12-3 1-(5-(benzyloxy)-7-propionylbenzo[d]thiazol-2-yl)-3-ethylurea 
• 1372548-11-2 1-(5-(benzyloxy)-7-cyanobenzo[d]thiazol-2-yl)-3-ethylurea 
• 1372548-48-5 1-(5-(Benzyloxy)-7-formylbenzo[d]thiazol-2-yl)-3-ethylurea 
• 1372548-49-6 (E)-1-(5-(benzyloxy)-7-((methoxyimino)methyl)benzo[d]thiazol-2-yl)-3-ethylurea 
• 1372548-65-6 1-[5-benzyloxy-7-(1-ethoxyvinyl)-1,3-benzothiazol-2-yl]-3-ethyl-urea 
• 1372548-66-7 1-(7-acetyl-5-benzyloxy-1,3-benzothiazol-2-yl)-3-ethyl-urea 
• 1372548-67-8 1-[5-benzyloxy-7-[(E)-N-methoxy-C-methyl-carbonimidoyl]-1,3-benzothiazol-2-yl]-3-ethyl-urea 
• 1372546-35-4 1-[5-[2-(ethylcarbamoylamino)-7-(2-pyridyl)-1,3-benzothiazol-5-yl]pyrimidin-2-yl]-4-phenyl-piperidine-4-carboxylic acid 

Relevant academic research and scientific papers

MACROCYCLIC RIP2-KINASE INHIBITORS

The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

Antibacterial Compounds

The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors

The discovery and optimisation of a new class of benzothiazole small molecules that inhibit bacterial DNA gyrase and topoisomerase IV are described. Antibacterial properties have been demonstrated by activity against DNA gyrase ATPase and potent activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes and Haemophilus influenzae. Further refinements to the scaffold designed to enhance drug-likeness included analogues bearing an α-substituent to the carboxylic acid group, resulting in excellent solubility and favourable pharmacokinetic properties.

ANTIBACTERIAL COMPOUNDS

The present invention provides a compound of the following formula and salts thereof: Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

ANTIBACTERIAL COMPOSITIONS

Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1 ; Q is hydrogen or cyclopropyl; AIk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynylene radical which may contain an ether (-O-), thioether (-S-) or amino (-NR)- link, wherein R is hydrogen, -CN or C1-C3 alkyl; X is -C(=O)NR6-, -S(O)NR6-, -C(=O)O- or -S(=O)O- wherein R6 is hydrogen, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -Cyc, or -( C1-C3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms; Z is N or CH, or CF; R2 and R3 are as defined in the description.

Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists

The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.

Nucleophilic Substitution of Nitrite in Nitrobenzenes, Nitrobiphenyls and Nitronaphthalenes

Aromatic compounds, accessible only by multistep procedures, can be synthesized easily by nucleophilic substitution of nitrite in nitrobenzenes, nitrobiphenyls, and nitronaphthalines.Thus, meta-substituted phenols 3, 4, and 7 are obtained from 1,3-dinitrobenzene (1) and meta-substituted nitrobenzenes 6, as well as 3,5-disubstituted phenols 10 and 5-substituted resorcinol derivatives 11 from 3,5-disubstituted nitrobenzenes 9.The unsymmetrically substituted nitrobiphenyls 13, 15, 17, 19, 23, 24, and 26 are also available by nitrite exchange from the corresponding easily accessible dinitrobiphenyls 16, 18, 20, 22, and 25.A nitrite exchange with nucleophiles is easily possible in the 1,5-disubstituted naphthalenes 29, 34, while in the case of the 1,8-disubstituted naphthalenes 31, 36 only the chloro derivative 36 undergoes this exchange under much stronger conditions in low yield.