128942-68-7

Basic information

• Product Name: 6-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 6-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 128942-68-7
• Molecular Weight: 253.344
• Mol File: 128942-68-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(128942-68-7)
• EPA Substance Registry System: 6-methoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline(128942-68-7)

Safety Data

• Hazardous Substances Data: 128942-68-7(Hazardous Substances Data)

Upstream product

• 13114-23-3 4-methoxybenzyl-N-methylimine 
• 54893-54-8 6‐methoxy‐N‐methyl‐1,2,3,4‐tetrahydroisoquinoline 
• 108-90-7 chlorobenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 128942-59-6 2-[(4-Methoxy-benzyl)-methyl-amino]-1-phenyl-ethanone 
• 702-24-9 4-methoxy-N-methylbenzylamine 
• 128942-64-3 2-[(4-methoxy-benzyl)-methyl-amino]-1-phenyl-ethanol 

Relevant articles and documents

4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors

Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.

A New Synthesis of 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines

1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquinolines 6 are obtained from aromatic aldehydes 1, methyl amine and α-haloacetophenones 2 in the presence of sodium borohydride followed by cyclization with sulfuric acid and zinc in methanol.