1201-07-6

Usage

Uses

8-Bromo-4-chloro-2-methylquinoline is a useful chemical for research.

InChI:InChI=1/C10H7BrClN/c1-6-5-9(12)7-3-2-4-8(11)10(7)13-6/h2-5H,1H3

Upstream product

• 128942-73-4 C₁₂H₁₄BrNO₂ 
• 615-36-1 2-bromoaniline 
• 1201-08-7 2-methyl-4-hydroxy-8-bromo-quinoline 

Downstream Products

• 1121528-69-5 N-[(2,3-dichlorophenyl)methyl]-2-methyl-4-quinolinamine 

Relevant academic research and scientific papers

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

Quinoline and quinazoline derivatives having corticotropin releasing factor (CRF) antagonist activity

The present invention relates to novel compounds, to a method for the preparation of these novel compounds, to pharmaceutical compositions containing one or more of these compounds as an active component and to methods of using these in the treatment of s