1201-07-6

Basic information

• Product Name: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
• Synonyms: 8-BROMO-4-CHLOROQUINALDINE;8-BROMO-4-CHLORO-2-METHYLQUINOLINE;2-Methyl-4-chloro-8-BroMoquinoline
• CAS NO: 1201-07-6
• Molecular Formula: C₁₀H₇BrClN
• Molecular Weight: 256.53
• Mol File: 1201-07-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 321.854 °C at 760 mmHg
• Flash Point: 148.452 °C
• Appearance: /
• Density: 1.591 g/cm³
• Vapor Pressure: 0.000546mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE(1201-07-6)
• EPA Substance Registry System: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE(1201-07-6)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1201-07-6(Hazardous Substances Data)

Usage

Uses

8-Bromo-4-chloro-2-methylquinoline is a useful chemical for research.

InChI:InChI=1/C10H7BrClN/c1-6-5-9(12)7-3-2-4-8(11)10(7)13-6/h2-5H,1H3

Upstream product

• 615-36-1 2-bromoaniline 
• 128942-73-4 C₁₂H₁₄BrNO₂ 
• 1201-08-7 2-methyl-4-hydroxy-8-bromo-quinoline 

Downstream Products

• 1121528-69-5 N-[(2,3-dichlorophenyl)methyl]-2-methyl-4-quinolinamine 

Relevant articles and documents

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.