1289485-68-2

Basic information

• Product Name: N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide
• Synonyms: N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide
• CAS NO: 1289485-68-2
• Molecular Weight: 311.789
• Mol File: 1289485-68-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide(1289485-68-2)
• EPA Substance Registry System: N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide(1289485-68-2)

Safety Data

• Hazardous Substances Data: 1289485-68-2(Hazardous Substances Data)

Upstream product

• 80460-34-0 2-(5-chloro-2-hydroxy-phenyl)-isoindole-1,3-dione 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 6373-47-3 2-(benzyloxy)-5-chloroaniline 
• 124-63-0 methanesulfonyl chloride 
• 1289485-53-5 C₂₁H₁₄ClNO₃ 

Downstream Products

• 1289485-97-7 N-(2-(benzyloxy)-5-chlorophenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide 

Relevant articles and documents

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase

Cyclooxygenase-1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) are enzymes in two different pathways in the inflammatory process. In the present study, a variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes. Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor. Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.