1290104-79-8Relevant academic research and scientific papers
Synthesis of endo- and exo-N-Protected 5-Arylated 2-Aminothiazoles through Direct Arylation: An Efficient Route to Cell Differentiation Accelerators
Dao-Huy, Toan,Waldner, Birgit J.,Wimmer, Laurin,Schnürch, Michael,Mihovilovic, Marko D.
, p. 4765 - 4771 (2015)
An improved protocol for the direct arylation of N-phenyl-N-benzyl(thiazol-2-yl)amine by using aryl bromides as aryl donors is reported. The procedure was compared with a previously reported protocol in which aryl iodides were used as arylating agents. The improved direct arylation protocol was applied to structurally isomeric and nonaromatic 3-benzyl-N-phenylthiazol-2(3H)-imine. The two substrates for direct arylation were obtained from a common starting material, N-phenyl(thiazol-2-yl)amine, which was regioselectively benzylated either on the exo-cyclic or the endo-cyclic nitrogen by using two sets of reaction conditions. For the arylation of the isomeric nonaromatic 3-benzyl-N-phenylthiazol-2(3H)-imine, exclusive regioselectivity in the 5-position could be achieved.
Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters
Schnürch, Michael,Waldner, Birgit,Hilber, Karlheinz,Mihovilovic, Marko D.
experimental part, p. 2149 - 2154 (2011/04/24)
A series of N-arylthiazole-2-amines was prepared and their biological activity for the promotion of skeletal muscle cell differentiation was investigated, a process of significant importance in muscle regeneration. A versatile new synthetic route towards
