129015-69-6

Basic information

• Product Name: 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE
• Synonyms: 5-CHLORO-3-(TRIFLUOROMETHYL)PYRID-2-YL HYDRAZINE;1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE;1-[5-Chloro-3-(trifluoromethyl)-2-pyridyl]hydrazine, Tech.;5-Chloro-2-hydrazinyl-3-(trifluoroMethyl)pyridine
• CAS NO: 129015-69-6
• Molecular Formula: C₆H₅ClF₃N₃
• Molecular Weight: 211.57
• Mol File: 129015-69-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 75 °C
• Boiling Point: 244.6 °C at 760 mmHg
• Flash Point: 101.8 °C
• Appearance: /
• Density: 1.57 g/cm³
• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• PKA: 8.10±0.70(Predicted)
• CAS DataBase Reference: 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE(129015-69-6)
• EPA Substance Registry System: 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE(129015-69-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 129015-69-6(Hazardous Substances Data)

Usage

General Description

1-[5-Chloro-3-(trifluoromethyl)-2-pyridyl]hydrazine is a chemical compound that belongs to the class of organic compounds known as hydrazones. These compounds are characterized by the presence of a carbon-nitrogen covalent bond where a carbon atom from a carbonyl Halide group is doubly bonded to a nitrogen atom. The chemical carries a molecular formula of C6H4ClF3N2, indicating its composition comprises of carbon, hydrogen, chlorine, fluorine, and nitrogen. Despite its extensive nomenclature, specific applications of this compound are not widely documented in scientific literature, and as such, its specific safety measures, physical and chemical properties, possible health effects, and environmental impacts are not extensively outlined.

InChI:InChI=1/C6H5ClF3N3/c7-3-1-4(6(8,9)10)5(13-11)12-2-3/h1-2H,11H2,(H,12,13)

Upstream product

• 70158-59-7 2,5-dichloro-3-(trifluoromethyl)pyridine 

Downstream Products

• 1100365-46-5 C₁₁H₅Cl₃F₃N₅ 

Relevant articles and documents

Synthesis of 1,3-diazepines and ring contraction to cyanopyrroles

Several tetrazolo[1,5-a]pyridines/2-azidopyridines undergo photochemical nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4, 6-tetraenes (7,10,13,16,19,22) as well as ring cleavage to cyanovinylketenimines (8,17,20b) in low temperature Ar matrices. 6,8-Dichlorotetrazolo[1,5-a]pyridine/2-azido-3,5-dichloropridine 6 undergoes ready exchange of the chlorine in position 8 (3) with ROH/RONa. 8-Chloro-6-trifluoromethylletrazolo[1,5-a]pyridine 15 undergoes solvolysis of the CF3 group to afford 8-chloro-6-methoxycarbonyltetrazolo[1,5-a]pyridine 18. Several tetrazolopyridines/2-azidopyridines afford 1H- or 5H-1,3-diazepines in good yields on photolysis in the presence of alcohols or amines (11,14,23,25). 5-Chlorotetrazolo[1,5-a]pyridines/2-azido-6-chloropyridines 21 and 38 undergo a rearrangement to 1H-and 3H-3-cyanopyrroles 27 and 45, respectively. The mechanism of this rearrangement was investigated by 15N-labelling and takes place via transient 1,3-diazepines. The structures of 6,8-dichloro-tetrazolo[1,5-a]pyridine 6T, 6-chloro-8-ethoxytetrazoIo[1,5-a]pyridine 9Tb, dipyrrolylmethane 28, and 2-isopropoxy-4-dimethylamino-5H-1,3-diazepine 25b were determined by X-ray crystallography. In the latter case, this represents the first reported X-ray crystal structure of a 5H-1,3-diazepine.