129017-77-2

Upstream product

• 33487-17-1 Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate 
• 129100-11-4 (S)-1-(1-Oxa-spiro[2.5]oct-2-yl)-methanol 
• 108-94-1 cyclohexanone 
• 932-89-8 2-cyclohexylidene ethanol 
• 183997-42-4 (R)-1-Oxa-spiro[2.5]octane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 1617-22-7 cyclohex-1-enecarboxylic acid ethyl ester 
• 862419-69-0 1-(p-tolylsulfinyl)-2-(cyclohexen-1-yl)-2-ethanone 
• 862419-78-1 1-(p-tolylsulfanyl)-2-(cyclohexen-1-yl)-2-ethanone 
• 203253-78-5 (-)-8-Phenylmenthyl α-(cyclohex-1-enyl)-α-hydroxyacetate 
• 174867-35-7 methyl (-)-(αR)-α-hydroxycyclohex-1-eneacetate 
• 40203-74-5 methyl 2-cyclohexylideneacetate 
• 6975-17-3 ethyl 1-oxaspiro[2.5]octane-2-carboxylate 

Downstream Products

• 129017-78-3 (R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-cyclohex-1-enyl-ethanol 
• 183322-95-4 (R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-cyclohex-1-enyl-ethanol 
• 67101-72-8 (+/-)-(2E)-2-cyclohex-1-enyl-oxirane 

Relevant academic research and scientific papers

Highly enantioselective synthesis of multifunctionalized allylic building blocks via oxazaborolidine-catalyzed borane reduction

A simple and convenient synthesis of optically active alkenyl β-hydroxy sulfides with high enantiomeric excess by CBS-oxazaborolidine- catalyzed borane reduction of the corresponding β-keto sulfides and its application to synthesis of chiral alkenic diols have been established.

Asymmetric induction in Darzens condensation by means of (-)-8-phenylmenthyl and (-)-menthyl auxiliaries

Asymmetric Darzens condensation of benzaldehyde and various ketones has been investigated. The condensation of acetophenone, propiophenone and symmetric ketones with (-)-8-phenylmenthyl halogenoacetates 3a,b afforded the corresponding glycidic esters cis-12, cis-13 and 15-19 in 77-96% de, respectively, as the major products. Aza-Darzens condensation between N-benzylideneaniline and 3a occurred to give the trans-aziridine 21 as the major isomer in >85% de. The stereochemistry of the major diastereoisomers of cis-12 and 18 was confirmed by their conversion into the known optically active diols 22 and 24. The configuration of the major product of cis-12 was determined to be 2R,3R and that of 18 to be 2R. The geometric and disastereofacial selectivities were understandable in terms of the open-chain or non-chelated antiperiplanar transition state model in the initial aldol-type reaction.

Asymmetric epoxidation of chiral allylic alcohols

Two series of chiral allylic alcohols, derived from α,β-unsaturated cyanohydrins, were subjected to asymmetric epoxidation under a variety of conditions. Both achiral (organic peracid, metal-catalyzed peroxide) and chiral (Sharpless titanium-tartrate syst

A convenient synthesis of vinyl epoxides from glycidic esters via α-hydroxy-β,γ-unsaturated esters

Glycidic esters, upon isomerisation with BF3.ET2O yield α-hydroxy-β,γ-unsaturated esters. These are then reduced with LiAlH4 to vicinal diols which are converted to vinyl epoxides in two steps.

Conformationally restricted leukotriene antagonists. Asymmetric synthesis of a nor-leukotriene D4 analog. II1

Chiral diol 5 is prepared from cyclohexanone and used in the asymmetric synthesis of nor-leukotriene D4 analog 1.