33487-17-1

Basic information

• Product Name: Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate
• Synonyms: Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate
• CAS NO: 33487-17-1
• Molecular Weight: 184.235
• Mol File: 33487-17-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate(33487-17-1)
• EPA Substance Registry System: Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate(33487-17-1)

Safety Data

• Hazardous Substances Data: 33487-17-1(Hazardous Substances Data)

Upstream product

• 6975-17-3 ethyl 1-oxaspiro[2.5]octane-2-carboxylate 
• 105378-19-6 [2-Phenylselanyl-cyclohex-(E)-ylidene]-acetic acid ethyl ester 
• 188531-01-3 [1-(4-Nitro-benzenesulfonyloxy)-cyclohexyl]-oxo-acetic acid ethyl ester 
• 13275-31-5 ethyl cyclohexyloxoacetate 
• 188530-92-9 Cyclohexylidene-trimethylsilanyloxy-acetic acid ethyl ester 
• 50984-16-2 rac-2-(phenylseleno)cyclohexanone 
• 108-94-1 cyclohexanone 

Downstream Products

• 124957-26-2 ethyl 2-cyclohex-1-enyl-2-oxoacetate 
• 67101-72-8 (+/-)-(2E)-2-cyclohex-1-enyl-oxirane 
• 178960-16-2 ethyl-2-acetoxy-2-(cyclohex-1-ene)-acetate 
• 129017-77-2 cyclohex-1-enyl-ethane-1,2-diol 
• 178960-22-0 (S)-Cyclohex-1-enyl-hydroxy-acetic acid ethyl ester 
• 178960-29-7 (S)-2-Cyclohex-1-enyl-oxirane 
• 183322-93-2 (S)-1-(cyclohexen-1-yl)-1,2-ethanediol 
• 79605-68-8 (1R)-1-(cyclohex-1-en-1-yl)ethan-1-ol 
• 222179-92-2 2-cyclohex-1-enyl-3,3,3-trifluoro-2-hydroxy-propionic acid ethyl ester 
• 222179-93-3 2-cyclohex-1-enyl-3,3,3-trifluoro-propane-1,2-diol 

Relevant articles and documents

HClO4·SiO2-mediated improved isomerization of glycidic esters to α-hydroxy-β,γ -unsaturated esters: Application in the formal synthesis of (R)-Baclofen and β-phenyl GABA analogues

An efficient isomerization of glycidic esters to corresponding allylic alcohols, viz. α-hydroxy-β,γ -unsaturated esters has been brought about using HClO4·SiO2. Five of these allylic alcohols underwent selective SN2' nucleophilic substitution to generate γ-azido-α,β-unsaturated esters which were readily converted to an antispastic drug Baclofen and four other β-phenyl GABA analogues.

Synthesis and Reactions of 3-(Nosyloxy)-2-keto Esters

A series of 3-(nosyloxy)-2-keto esters 7a-j were prepared from the corresponding α-keto esters by conversion to the trimethylsilyl enol ether and reaction with p-nitrobenzenesulfonyl peroxide. Conversion of these materials to 1,2,3-trifunctionalized compounds is described, and comparison of their properties with isomeric 2-(nosyloxy)-3-keto esters is discussed.

Syntheses d'alcools allyliques et alleniques fonctionnels a partir de composes carbonyles α-phenylselenies

The functionalized allylic selenides 6, 7, 8, 10 and 11 were prepared from phenylselenoaldehydes and ketones 1, and phenylselenopyruvates 2 using the Wittig or the Horner reaction. 2,3-Sigmatropic rearrangement of the corresponding selenoxides leads to the functional allylic alcohols 15, 16 and 17 and to the conjugated enals 18, 19 and 20.A method for the conversion of an aldehyde into the enal with an additional carbon is described.The functional 3-phenylselenobutadienes 23, 24 and 25 were also obtained from α-phenylselenoenals 21 in the same manner.An oxidation-rearrangement reaction appears to be a convenient way to prepare the functional or substitued allenic alcohols 26 and 28.The ethyl 2-hydroxy pent-3,4-dienoate 26c has been cyclized by benzeneselenenyl bromide into the ethyl 2,5-dihydrofurancarboxylate 29.