6975-17-3

Usage

Uses

Used in Flavor and Perfume Industry:
ETHYL 1-OXASPIRO[2.5]OCTANE-2-CARBOXYLATE is used as a flavoring agent for its unique fruity aroma, enhancing the taste and smell of various food products and beverages.
Used in Fragrance Production:
ETHYL 1-OXASPIRO[2.5]OCTANE-2-CARBOXYLATE is used as a perfume ingredient, contributing to the creation of complex and appealing scents in perfumes, soaps, and cosmetics.
Used in Cosmetics:
ETHYL 1-OXASPIRO[2.5]OCTANE-2-CARBOXYLATE is used as a fragrance component in cosmetics, providing a pleasant scent and enhancing the sensory experience of using these products.
Used in Soap Manufacturing:
ETHYL 1-OXASPIRO[2.5]OCTANE-2-CARBOXYLATE is used as a scent ingredient in soaps, adding a refreshing and fruity aroma to the final product.
Used as an Intermediate in Organic Synthesis:
ETHYL 1-OXASPIRO[2.5]OCTANE-2-CARBOXYLATE is used as a chemical intermediate for the synthesis of other organic compounds, showcasing its utility in various chemical processes and applications.

InChI:InChI=1/C10H16O3/c1-2-12-9(11)8-10(13-8)6-4-3-5-7-10/h8H,2-7H2,1H3

Upstream product

• 39794-75-7 ethyl α-p-toluenesulfonyloxyacetate 
• 34434-35-0 Natrium-Verbindung des Cyclohexanons 
• 141-52-6 sodium ethanolate 
• 108-94-1 cyclohexanone 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 120-92-3 cyclopentanone 
• 114091-85-9 ethyl 2-bromo-2-(1-hydroxycyclohexyl)acetate 
• 114091-86-0 chloro-(1-hydroxy-cyclohexyl)-acetic acid ethyl ester 

Downstream Products

• 55043-47-5 Hydroxy-(1-methoxy-cyclohexyl)-acetic acid ethyl ester 
• 35610-74-3 5-cyclohexylidene-3-phenyl-2-thioxo-thiazolidin-4-one 
• 91492-25-0 α-Guanidino-cyclohexyliden-essigsaeure 
• 35713-21-4 2-amino-5-(1-hydroxy-cyclohexyl)-thiazol-4-one 
• 40894-17-5 1-(2-hydroxyethyl)cyclohexanol 
• 33487-17-1 Ethyl 2-hydroxy-2-(2-cyclohexenyl) acetate 
• 13275-31-5 ethyl cyclohexyloxoacetate 
• 5326-50-1 (1-hydroxycyclohexyl)acetic acid ethyl ester 
• 117668-87-8 (1-Hydroxy-cyclohexyl)-phenylselanyl-acetic acid ethyl ester 
• 91057-85-1 ethyl 1-hydroxy-α-hydroxycyclohexaneacetate 
• 83769-21-5 (1-Fluoro-cyclohexyl)-hydroxy-acetic acid ethyl ester 
• 2916-10-1 1-oxa-spiro[2.5]octane-2-carboxylic acid allyl ester 
• 83769-29-3 ethyl 2-(1-fluorocyclohexyl)pyruvate 
• 35610-71-0 2-amino-5-cyclohexylidene-thiazol-4-one 

Relevant academic research and scientific papers

HClO4·SiO2-mediated improved isomerization of glycidic esters to α-hydroxy-β,γ -unsaturated esters: Application in the formal synthesis of (R)-Baclofen and β-phenyl GABA analogues

An efficient isomerization of glycidic esters to corresponding allylic alcohols, viz. α-hydroxy-β,γ -unsaturated esters has been brought about using HClO4·SiO2. Five of these allylic alcohols underwent selective SN2' nucleophilic substitution to generate γ-azido-α,β-unsaturated esters which were readily converted to an antispastic drug Baclofen and four other β-phenyl GABA analogues.

The synthesis of solvent-free glycidic esters from diazoesters and carbonyl compounds catalysed by lanthanide trifiates

The results of the reaction between ethyl diazoacetate and carbonyl compounds catalysed by lanthanide triflates are described. Aldehydes, and α-unsubstituted and α-monosubstituted cyclohexanones react to give the selective formation of α,β-epoxy esters (g

Mechanism of formation of 5,5-cyclopentamethylene-3,4-dicarbethoxyfuranone-2 from ethyl β,β-pentamethyleneglycidate and diethyl malonate

An O18 isotope study of the reaction of glycidate (1c) with diethyl malonate leading to a furanone diester (2d) reveal that there is a ring cleavage followed by an intramolecular cyclisation.Isotopic evidence for the Darzen's reaction is given.The glycidate (1c) does not undergo cleavage with benzylamine, however with hydrogen chloride a chlorohydrin through the cleavage of the epoxide ring is obtained.

α-Bromo-, α-chloro-, and α-trimethylsilyl-zinc ester enolates. New and universal Reformatsky-type Darzens and Peterson reactions

Low temperature reactions of ethyl dihaloacetates with carbonyl compounds in the presence of zinc/silver-graphite give α-halo-β-hydroxyalkanoates, which are readily converted into glycidates by base.Unser the same conditions ethyl(bromo)(trimethylsilyl) acetate with aldehydes and ketones forms α,β-unsaturated esters by a Reformatsky-Peterson reaction combination.

Methode generale d'obtention des α-ceto esters β-fluores

A general method of synthesis of 3-alkyl (or aryl) 3-fluoro 2-oxo esters is described.The opening of glycidic esters with HF-pyridine (70percent w/w) followed by oxidation with Jones reagent, give the corresponding derivatives of fluoropyruvic esters in good yields.

NEW SYNTHETIC ROUTES TO β-FLUORO β-PHENYLLACTIC ACID DERIVATIVES AND Β-FLUOROCYANOHYDRINS

Alkyl phenyl 2,3-epoxycarboxylates from the well-known Darzens glycidic esters synthesis react under very mild conditions with pyridinium-poly-hydrogen fluoride to give corresponding 3-fluoro 3-phenyllactates in almost quantitative yields with a high regio and stereoselectivity.This method can be applied succesfully to other flycidic derivatives: glycidoamides, glycidonitriles, glycidoiminoesters...The spectrometric properties (IR, NMR) are presented.