129044-97-9Relevant academic research and scientific papers
Synthesis, Crystal Structure and Anti-leukemic Activity of 4-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline
Guillon, Jean,Moreau, Stéphane,Desplat, Vanessa,Vincenzi, Marian,Pinaud, No?l,Savrimoutou, Solène,Rubio, Sandra,Ronga, Luisa,Rossi, Filomena,Marchivie, Mathieu
, p. 106 - 112 (2018/09/27)
Abstract: The title compound 4-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-3-phenyl-3H-pyrrolo[2,3-c]quinoline 1, a compound that showed cytotoxic potential against two leukemia cell lines, has been synthesized via a multi-step
THERAPEUTIC COMPOUNDS
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, (2018/07/06)
no abstract published
Macrocyclic Compounds As Antiviral Agents
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, (2010/08/07)
A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
Phenylpyrrolic compounds used as drugs, their preparation and application
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, (2008/06/13)
The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.
Compounds interacting with tubulin: Part I: Synthesis of ortho-ortho' substituted phenylpyrroles with free or restricted rotation.
Alazard, JP.,Boye, O.,Gillet, B.,Guenard, D.,Beloeil, JC.,Thal, C.
, p. 779 - 787 (2007/10/02)
The synthesis of ortho-ortho' substituted phenylpyrroles that are susceptible to isomerization of the biaryl type (atropisomerism) was performed using a Michael addition of isocyanoacetates with nitrostyrenes.Atropisomerism in phenylpyrroles 14 and 15 was studied by means of 1H NMR spectroscopy using chiral lanthanide shift reagents (LSR*).In the case of chiral phenylpyrrole 21, an evaluation of the interconversion parameters between diastereomers (k, ΔGT*) was attempted. - - - tubulin / phenylpyrrole / atropisomers / chiral shift reagents
