180338-29-8

Upstream product

• 186581-53-3 diazomethane 
• 180338-28-7 1,3-Dimethyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid 
• 67-56-1 methanol 
• 180338-27-6 1-[1,3-Dimethyl-4-(2-nitro-phenyl)-1H-pyrrol-2-yl]-2,2,2-trifluoro-ethanone 
• 180338-24-3 1,4-dimethyl-3-(2-nitrophenyl)-1H-pyrrole 
• 129044-98-0 1,4-dimethyl-3-(2'-nitrophenyl)pyrrole-2-carboxylate d'ethyle 
• 129044-99-1 acide 1,4-dimethyl-3-(2-nitrophenyl)-1H-pyrrole-2-carboxylique 

Downstream Products

• 180338-31-2 5-(3-Ethoxycarbonyl-propionyl)-1,3-dimethyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 180338-34-5 4-[3-(2-Amino-phenyl)-1,4-dimethyl-1H-pyrrol-2-yl]-butyric acid 
• 180338-33-4 4-[1,4-Dimethyl-3-(2-nitro-phenyl)-1H-pyrrol-2-yl]-butyric acid 
• 180338-32-3 5-(3-Ethoxycarbonyl-propyl)-1,3-dimethyl-4-(2-nitro-phenyl)-1H-pyrrole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Compounds interacting with tubulin. Part II fll : Synthesis of tricyclic lactams with a phenylpyrrole framework, structural analogs of rhazinilam

The biolooical interest of rhazinilam 1 led us to synthesize the tricydic lactam analogs 4-9 with different alkyl substituents in the a and β positions on the pyrrole ring, and different sizes of the lactam ring (6-, 7-, 8- and 9-membered). These compounds were prepared from arylpyrrole 12 (access to lactams 4-8) and arylpyrrole 49 (access to lactam 9). The in vitro biological activities of all these analogs (evaluated by an antitubulin test) were found to be inferior to that of rhazinilam 1, but were nevertheless of the same type. The results are discussed. Elsevier,.