129050-26-6Relevant articles and documents
PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL
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Page/Page column 29-32, (2017/08/20)
The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl) chromans of formula I. The intermediates thus obtained can be used for the sy
METHOD FOR PREPARING NEBIVOLOL
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Page/Page column 7, (2011/10/12)
The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.
Asymmetric-catalysed preparation and stereochemistry of (R,R)-,(S,R)-(6-fluoro-2-chromanyl)-1,2-ethanediol
Yang, Yun-Xu,Liu, Shi-Xiang
, p. 506 - 508 (2008/09/21)
(R,R)-,(S,R)-1-(6-fluoro-2-chromanyl)-1,2-ethanediol 1a/1b were prepared by hydrolytic kinetic resolution (HKR) of terminal racemic epoxides using (R,R)-SalenCo(OAc) as a catalyst. Their configurations were established by comparison with two authentic samples by HPLC.