129053-74-3

Upstream product

• 129053-73-2 3-methyl-2-phenylmethylaminocyclohex-2-en-1-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 23456-78-2 1,4,5,6-tetrahydro-7H-indol-7-one 
• 765-87-7 cyclohexane-1,2-dione 
• 108153-93-1 7-oxo-4,5,6,7-tetrahydrobenzofuran 
• 24461-61-8 phenylglycine methyl ester 
• 100-46-9 benzylamine 
• 100-44-7 benzyl chloride 
• 21889-89-4 2,3-epoxy-3-methylcyclohexanone 

Downstream Products

• 1236887-86-7 1-benzyl-6-[(dimethylamino)methylene]-1,4,5,6-tetrahydro-7H-indole-7-one 
• 1429642-05-6 C₁₆H₁₄N₂O 
• 1314094-24-0 1-benzyl-6-(hydroxymethylene)-1,4,5,6-tetrahydro-7H-indole-7-one 
• 1314093-88-3 9-benzyl-3,5,6,9-tetrahydro-2H-pyrrolo[3,2-h]quinazoline-2-one 
• 1314093-96-3 2-anilino-9-benzyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 
• 1314094-07-9 2-amine-9-benzyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 
• 1314093-84-9 9-benzyl-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 

Relevant academic research and scientific papers

Formation of N-substituted 4- and 7-oxo-4,5,6,7-tetrahydroindoles revisited: A mechanistic interpretation and conversion into 4- and 7-oxoindoles

An efficient method for the preparation of 4-oxo-4,5,6,7-tetrahydroindoles was successfully applied to the synthesis of N-substituted 7-oxo-4,5,6,7- tetrahydroindoles for the first time. Both isomers where converted into their corresponding 4- and 7-oxoindoles in good yields utilizing a novel aromatization protocol. Based on the impurity profile obtained, however, different mechanisms for the formation of the 4- and 7-oxo-4,5,6,7-tetrahydroindole derivatives are discussed. In addition, the reaction sequences appear to be stereospecific allowing for the direct introduction of a chiral center α to the nitrogen and preparation of enantiomerically enriched products.

PHOTOCHEMOTHERAPEUTIC HETEROCYCLIC AGENTS HAVING ANTIPROLIFERATIVE AND ANTINEOPLASTIC ACTIVITY

The present invention concerns the synthesis of new analogs of angelicins, pyrrolo [3,2-h]quinoline, for the treatment of pathologies having hyperproliferative character included those having neoplastic nature. The treatment is based on the combined actio

Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage

In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline - bioisosters of the angular furocoumarin angelicin - were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity against a panel of four human tumor cell lines and a great dose UV-A dependence, reaching IC50 values at submicromolar level. The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action.

Dihydroindol-7(6H)-ones and 6,7-Dihydropyrroloazepine-4,8(1H,5H)-dione

3-Methylcyclohexenones may be converted into dihydroindol-7(6H)-ones by conversion of the epoxide into the 2-benzylamino-3-methylcyclohexenone, which reacts with dimethylformamide dimethyl acetal to give N-benzyldihydroindol-7(6H)-ones.The limitations of the process are discussed, as is the failure to convert the dihydroindol-7(6H)-ones into dihydropyrroloazepinediones by Beckmann or Schmidt rearrangements.An example of the latter compounds was made by a simple procedure from pyrrolecarboxylic acid.