129097-23-0

Upstream product

• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 67219-55-0 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 
• 110838-39-6 N,N,N',N'-Tetraisopropyl-P-methylphosphonous diamide 

Downstream Products

• 128981-15-7 C₅₀H₅₂N₅O₁₃PS 
• 128980-94-9 Methyl-phosphinothioic acid O-{(2S,3R,5S)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester 
• 183480-93-5 N⁴-benzoyl-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate 
• 183480-92-4 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-2'-deoxyguanosine 3'-methylphosphonate 
• 183480-91-3 N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidylyl-(3'-5')-N²-isobutyryl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyguanosine 3'-methylphosphonate 

Relevant academic research and scientific papers

OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND ENZYMIC DEGRADATION

The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.

Synthesis of Alkylphosphon(othio)ate Analogues of DNA

Easily accessible bis(diisopropylamino)alkylphosphines (alkyl is methyl, n-butyl or n-octyl) are convenient reagents for the synthesis of DNA fragments having an alkylphosphonate or alkylphosphonothioate linkage at a predetermined site in solution and on