Tetrahedron Letters p. 3539 - 3542 (1987)
Update date:2022-08-05
Topics:
Agrawal, Sudhir
Goodchild, John
The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.
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