129098-55-1

Basic information

• Product Name: (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE
• Synonyms: (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE
• CAS NO: 129098-55-1
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07056
• Mol File: 129098-55-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE(129098-55-1)
• EPA Substance Registry System: (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE(129098-55-1)

Safety Data

• Hazardous Substances Data: 129098-55-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of medicinal agents, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is employed as a building block for the production of different agrochemicals. Its versatility in chemical reactions enables the synthesis of various compounds used in agriculture, such as pesticides and herbicides, to improve crop protection and yield.
Used in Fine Chemicals Production:
(S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE is also used as an intermediate in the production of fine chemicals. These specialty chemicals are used in various applications, including fragrances, dyes, and coatings, where their unique properties are highly valued.
Safety Precautions:
It is crucial to handle (S)-2-((4-BROMOPHENOXY)METHYL)OXIRANE with care and adhere to proper safety protocols due to its potential hazards. As with any chemical compound, appropriate measures should be taken to minimize risks and ensure the safety of those working with it.

Upstream product

• 2212-06-8 2-((4-bromophenoxy)methyl)oxirane 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 106-41-2 4-bromo-phenol 
• 124-38-9 carbon dioxide 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 70987-78-9 (S)-Glycidyl tosylate 

Downstream Products

• 1058159-21-9 (S)-5-(4-bromo-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine 
• 1279014-10-6 (S)-2-(2',3'-dichlorobiphenyl-4-yloxymethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one 
• 1058156-95-8 2(S)-(4-bromo-phenoxymethyl)-2,3(S)-dihydro-oxazolo[3,2-a]pyrimidin-7-one 
• 5610-10-6 1-(4-bromophenoxy)-3-morpholin-4-yl-propan-2-ol 
• 333747-15-2 C₁₉H₂₃O₂N₂Br 

Relevant articles and documents

CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein coupled receptor modulators which may be used as medicaments

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide

Among chiral macrocycles 1 synthesized, 1m with the 3,5-bis(trifluoromethyl)phenylethynyl group was the best organocatalyst for the enantioselective synthesis of cyclic carbonates from disubstituted or monosubstituted epoxides and CO2. The X-ray crystal structure of 1m revealed a well-defined chiral cavity with multiple hydrogen-bonding sites that is suitable for the enantioselective activation of epoxides. A catalytic cycle proposed was supported by DFT calculations.

SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones of formula (I) as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of

Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers

The phenyl glycidyl ether derivatives have been kinetically resolved with the growing cells of Bacillus alcalophilus MTCC10234 yielding (S)-epoxides with up to >99% ee and (R)-diols with up to 89% ee. The enantiomeric ratio (E) of up to 67 has been obtained for biohydrolysis process. The effect of different substituents of phenyl glycidyl ether on the biocatalytic efficiency of B. alcalophilus MTCC10234 showed preference for methyl- and chloro-substituted aryl glycidyl ether derivatives whereas nitro-derivatives were transformed at a slower rate. 2,6-Dimethylphenyl glycidyl ether which contains a bulky aryl group having methyl group on both the ortho positions was resolved with an E=39.

SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

Enantioselective incorporation of carbon dioxide into epoxides catalyzed by optically active cobalt(II) complexes

The enantioselective chemical fixation of CO2 into an epoxide was developed using an optically active ketoimi-natocobalt(II) complex as a chiral Lewis acid. In the presence of a catalytic amount of the cobalt complex and amine base, enantioselective CO2 fixation with an epoxide proceeded with kinetic resolution to afford the corresponding carbonate along with unreacted epoxide, both of which were optically active. To improve their enantioselectivities, the ligand structures of the cobalt complexes and amine bases were examined. Thus, the optimized catalytic system was successfully applied to various epoxides to obtain the corresponding optically active cyclic carbonates and to recover epoxides with good-to-high enantioselectivities.

CsF in organic synthesis. Regioselective nucleophilic reactions of phenols with oxiranes leading to enantiopure β-blockers

The two modes of the paths in the reaction of oxiranes with phenols are completely controlled by CsF. Glycidyl nosylate undergoes exclusive substitution at the C1 position whereas the ring-opening (C-3 attack) occurs with epichlorohydrin, glycidol, and 1,2-epoxyalkanes. These reactions provide convenient access to enantiopure β-blockers.

Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes

(matrix presented) The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained i