129115-54-4

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 107-91-5 cyanoacetic acid amide 
• 2826-22-4 4-fluorobenzylidenemalononitrile 
• 1352994-22-9 5-amino-3-(4-fluorophenyl)-2,3-dihydroisoxazole-4-carbonitrile 

Downstream Products

• 129115-56-6 C₁₇H₁₂FN₃O₂ 

Relevant academic research and scientific papers

Novel synthesis of 3-cyano-2-pyridones derivatives catalyzed by Au–Co/TiO2

Abstract: The current work described a new and highly selective method for the synthesis of substituted 3-cyano-2-pyridones scaffolds using gold-cobalt supported on TiO2 as a robust and recyclable catalyst. The products were successfully obtained by one-pot, multicomponent manner. This procedure generated the desired products 2-pyridones derivatives in good yields, from simple and available starting materials using heterogeneous and reusable catalyst. The diversity of 3-cyano-2-pyridones derivatives was prepared and characterized by IR, 1H and 13C NMR data and confirmed by element analysis data. Graphic abstract: [Figure not available: see fulltext.].

Tuning the Electronic Properties of 2-Cyano-3-phenylacrylamide Derivatives

We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C=O?H-N-C=O?H-N?); i.e., dimers are linked through dimeric N-H?O hydrogen bonds. The single-crystal X-ray structure shows molecules to be hydrogen-bonded dimers, which further form a parallel stacking arrangement, mediated by significant π-π interactions. The 1H NMR and fluorescence spectral studies indicate the coexistence of amide and iminol tautomers in solution, which can be influenced by the nature of the solvent. Further, the excitation-wavelength-dependent fluorescence spectrum and the biexponential fluorescence decay profiles suggest the presence of more than one emitting species; i.e., amide and iminol tautomers coexists in solution. We have also shown that the equilibrium between the two tautomers can be tuned by the judicious choice of electron-donating or -withdrawing substituents.

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.

Studies on activated nitriles: Synthesis of new 3-cyano-(p-antipyrylamino)-pyrazolopyrimidines and pyrazolotriazines

Reaction of ketene derivative 1 on treatment with 4-aminoantipyrine gives compound 2 with reacts with hydrazine to afford 5-amino-4-cyano-3-(p-antipyrylamino)pyrazole 3.Compound 3 on reaction with cinnamonitrile derivatives, α-acetyl ethyl cinnamate, ethyl acetoacetate, malonic acid derivatives, and chalcones furnishes respective pyrazolo pyrimidines.Diazonium salt of 3 yields pyrazolo triazines.