129135-66-6

Basic information

• Product Name: 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE
• Synonyms: 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE
• CAS NO: 129135-66-6
• Molecular Formula: C₁₁H₁₀BrNO
• Molecular Weight: 252.11
• Mol File: 129135-66-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE(129135-66-6)
• EPA Substance Registry System: 5-BROMOMETHYL-3-P-TOLYL-ISOXAZOLE(129135-66-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 129135-66-6(Hazardous Substances Data)

Upstream product

• 3235-02-7 p-methylbenzaldehyde oxime 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 106-96-7 propargyl bromide 

Downstream Products

• 191016-81-6 5-bromomethyl-3-(p-bromomethylphenyl)isoxazole 
• 147503-06-8 2-(3-(p-tolyl)isoxazol-5-yl)acetonitrile 
• 937189-02-1 C₁₁H₁₀N₄O 
• 191016-88-3 5-mercaptomethyl-3-(p-mercaptomethylphenyl)isoxazole 

Relevant articles and documents

Facile synthesis and docking studies of 7-hydroxyflavanone isoxazoles and acrylates as potential anti-microbial agents

The present study is aimed to synthesize the novel 7-hydroxyflavanone derived compounds and to assess their biological activity. Two series of compounds such as 2-phenyl-7-((3-phenylisoxazol-5-yl)methoxy)chroman-4-ones (6a–h) and 4-oxo-2-phenylchroman-7-yl acrylates (8a–k) were synthesized from 7-hydroxyflavanone. All the compounds were subjected to anti-microbial activity and molecular docking studies. The results showed that the compounds 6e, 6g–h, 8h–i and 8k were exhibited most potent anti-microbial activity when compared with the standard drugs. Further, the docking studies revealed that the compounds 6a and 8h have the highest binding affinity score of sterol 14-α demethylase and DNA gyrase B respectively. This is the first report assigning unique synthesis of 7-hydroxyflavanone derivatives and their anti-microbial activity proved with in silico studies. Furthermore, the present study is useful for constructive research to synthesize novel compounds along with their biological activity. [Figure not available: see fulltext.].

Product selectivity of thermal Buchner reaction of methyl 2-(3-arylisoxazol-5-yl)-2-diazoacetates with benzene, naphthalene and mesitylene, and ring-opening/closing reaction of products

Methyl 2-(3-arylisoxazol-5-yl)-2-diazoacetates were synthesized and the product selectivity of their thermal Buchner reaction with benzene, naphthalene and mesitylene was studied. The reaction of the isoxazolyl-substituted diazoacetates with benzene gave

Synthesis of 5-bromomethylisoxazoles and their reactions with secondary amines

Treating R-3-chloro-4-bromo-2-buten-1-ones with hydroxylamine hydrochloride afforded 3-alkyl(aryl, furyl)-5-bromomethylisoxazoles. By reaction of the latter with secondary amines new previously unknown aminoisoxazoles were synthesized. 2005 Pleiades Publi