129151-89-9

Basic information

• Product Name: 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
• Synonyms: 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
• CAS NO: 129151-89-9
• Molecular Weight: 325.364
• Mol File: 129151-89-9.mol

Chemical Properties

• CAS DataBase Reference: 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(129151-89-9)
• EPA Substance Registry System: 1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one(129151-89-9)

Safety Data

• Hazardous Substances Data: 129151-89-9(Hazardous Substances Data)

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 107967-05-5 [1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 107967-06-6 <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester 

Downstream Products

• 129151-94-6 cis-3-(acetyloxy)-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride 
• 129151-93-5 cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride 
• 129151-91-3 cis-1,3,4,5-tetrahydro-3-hydroxy-4-(methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-92-4 trans-1,3,4,5-tetrahydro-3-hydroxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-95-7 Acetic acid (3S,4R)-1-(2-dimethylamino-ethyl)-4-(4-methoxy-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester 
• 107967-13-5 (3S,4R)-1-(2-Dimethylamino-ethyl)-3-hydroxy-4-(4-methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 107967-08-8 1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 129151-90-2 1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 

Relevant articles and documents

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).